Clinical Trials
Friday, August 23rd, 2013
STROKEAHA: August 1, 2013 Background and Purpose—Mechanical thrombectomy using stent retriever devices have been advocated to increase revascularization in intracranial vessel occlusion. We present the results of a large prospective study on the use of the Solitaire Flow Restoration in patients with acute ischemic stroke. Methods—Solitaire Flow Restoration Thrombectomy for Acute Revascularization was an international, multicenter, […]
Clinical Trials
Friday, August 23rd, 2013
JACC: 8/1/13 Objectives To investigate whether the combination of conventional pulmonary vein isolation (PVI) by circumferential antral ablation with ganglionated plexi (GP) modification in a single ablation procedure, yields higher success rates than PVI or GP ablation alone, in patients with paroxysmal atrial fibrillation (PAF). Background Conventional PVI transects the major left atrial GP, and it is […]
Clinical Trials
Friday, August 23rd, 2013
STROKEAHA. July 18, 2013 Background—Atrial-based pacing is associated with lower risk of atrial fibrillation (AF) in sick sinus syndrome compared with ventricular pacing; nevertheless, the impact of site and rate of atrial pacing on progression of AF remains unclear. We evaluated whether long-term atrial pacing at the right atrial (RA) appendage versus the low RA septum […]
Clinical Trials
Thursday, August 1st, 2013
Jacc: August 2013 Objectives This study sought to determine whether post-operative neurocognitive dysfunction (POCD) occurs after ablation for atrial fibrillation (AF). Background Ablation for AF is a highly effective strategy; however, the risk of transient ischemic attack and stroke is approximately 0.5% to 1%. In addition, magnetic resonance imaging studies report a 7% to 14% prevalence of silent cerebral […]
Clinical Trials
Thursday, August 1st, 2013
STROKEAHA: July 30, 2013 Adherence to Consort Principles Background and Purpose—The 2001 Revised Consolidated Standards of Reporting of Trials (CONSORT) statement requires reporting of Randomized Controlled Trials (RCTs) to include participants’ baseline demographics. This enables comparison of intervention and control groups on potential confounding variables as well as assessment of study generalizability. Socioeconomic status (SES) is […]
Clinical Trials
Thursday, August 1st, 2013
STROKEAHA: July 30, 2013 Background and Purpose—Atrial fibrillation (AF) elevates risk of recurrent stroke but is incompletely identified by standard investigation after stroke, though detection rates correlate with monitoring duration. We hypothesized that 7 days of noninvasive cardiac-event monitoring early after stroke would accelerate detection of AF and thus uptake of effective therapy. Methods—We performed a […]
Clinical Trials
Thursday, August 1st, 2013
Wiley: JULY 29, 2013 The anatomy of carotid stenosis may influence the outcome of endovascular treatment or carotid endarterectomy. Whether anatomy favors one treatment over the other in terms of safety or efficacy has not been investigated in randomized trials. Methods In 414 patients with mostly symptomatic carotid stenosis randomized to endovascular treatment (angioplasty or stenting; n = 213) […]
Clinical Trials
Thursday, August 1st, 2013
STROKEAHA: July 25, 2013 Background and Purpose—In a previous study, 0.3 and 0.45 mg/kg of intravenous recombinant tissue plasminogen activator (rt-PA) were safe when combined with eptifibatide 75 mcg/kg bolus and a 2-hour infusion (0.75 mcg/kg per minute). The Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke–Enhanced Regimen (CLEAR-ER) trial sought to […]
Clinical Trials
Friday, July 26th, 2013
STROKEAHA: July 25, 2013 Background and Purpose—Acute treatments specifically for intracerebral hemorrhage (ICH) are being sought in randomized controlled trials. The treatment effect sizes in ongoing and future trials are likely to be small, necessitating large sample sizes. Methods—We searched online trial registries for randomized controlled trials investigating an acute treatment for ICH. For the trials […]
Clinical Trials
Friday, July 26th, 2013
Wiley: JUL 23, 2013 Recent publications describing the sobering global increase in stroke mortality and global life years lost due to stroke despite improvements in developed countries have drawn focus on the severe impact of stroke in the developing world. At the same time, three recent interventional trials that failed to demonstrate an important role […]
