Clinical Trials
Saturday, July 5th, 2014
STROKEAHA: June 10, 2014 Background and Purpose—A response-adaptive randomization (RAR) trial design actively adjusts the ratio of participants assigned to each trial arm, favoring the better performing treatment by using outcome data from participants already in the trial. Compared with a standard clinical trial, an RAR study design has the potential to improve patient participation in […]
Clinical Trials
Saturday, July 5th, 2014
CIRCULATIONAHA: April 30, 2014 Background—The PREDIMED (Prevención con Dieta Mediterránea) randomized primary prevention trial showed that a Mediterranean diet enriched with either extravirgin olive oil or mixed nuts reduces the incidence of stroke, myocardial infarction, and cardiovascular mortality. We assessed the effect of these diets on the incidence of atrial fibrillation in the PREDIMED trial. Methods […]
Clinical Trials
Saturday, July 5th, 2014
Wiley: 30 JUN 2014 Background and purpose The study aims to assess the recanalization rate in acute ischemic stroke patients who received no revascularization therapy, intravenous thrombolysis, and endovascular treatment, respectively, and to identify best clinical and imaging predictors of recanalization in each treatment group. Methods Clinical and imaging data were collected in 103 patients […]
Clinical Trials
Saturday, July 5th, 2014
STROKEAHA: June 10, 2014 Background and Purpose—A response-adaptive randomization (RAR) trial design actively adjusts the ratio of participants assigned to each trial arm, favoring the better performing treatment by using outcome data from participants already in the trial. Compared with a standard clinical trial, an RAR study design has the potential to improve patient participation in […]
Clinical Trials
Saturday, July 5th, 2014
STROKEAHA: June 10, 2014 Background and Purpose—The main objective of the present analysis was to assess the effect of treatment with aspirin compared with apixaban on ischemic stroke and major bleeding in women compared with men. Female patients with atrial fibrillation are at increased stroke risk compared with male patients, and the underlying reasons for higher […]
Clinical Trials
Saturday, July 5th, 2014
STROKEAHA: June 5, 2014 Background and Purpose—The aim of this study was to evaluate whether the remote introduction of electronic decision support tools into family practices improves risk factor control after first stroke. This study also aimed to develop methods to implement cluster randomized trials in stroke using electronic health records. Methods—Family practices were recruited from […]
Clinical Trials
Saturday, July 5th, 2014
CIRCULATIONAHA: June 3, 2014 Background—Nonvalvular atrial fibrillation (AF) is common in elderly patients, who face an elevated risk of stroke but difficulty sustaining warfarin treatment. The oral factor Xa inhibitor rivaroxaban was noninferior to warfarin in the ROCKET AF trial. This prespecified secondary analysis compares outcomes in older and younger patients. Methods and Results—There were 6229 […]
Clinical Trials
Saturday, July 5th, 2014
STROKEAHA: April 17, 2014 Background and Purpose—Because the diagnosis and treatment of carotid artery disease may reduce the rate of stroke, the aim of this study was to determine whether a diet intervention was associated with incident carotid artery disease. Methods—Participants were 48 835 postmenopausal women aged 50 to 79 years who were randomly assigned to […]
Clinical Trials
Monday, June 9th, 2014
STROKEAHA: May 15, 2014 Background and Purpose—We report on workflow and process-based performance measures and their effect on clinical outcome in Solitaire FR Thrombectomy for Acute Revascularization (STAR), a multicenter, prospective, single-arm study of Solitaire FR thrombectomy in large vessel anterior circulation stroke patients. Methods—Two hundred two patients were enrolled across 14 centers in Europe, Canada, […]
Clinical Trials
Monday, June 9th, 2014
Wiley- International Journal of Stroke: 5/15/14 Rationale Cooling reduced infarct size and improved neurological outcomes in animal studies modeling ischemic stroke, and also improved outcome in randomized clinical trials in patients with hypoxic-ischemic brain injury after cardiac arrest. Cooling awake patients with ischemic stroke has been shown feasible in phase II clinical trials. Primary aim To […]
