Coronary Artery Disease and Risk of Major Vascular Events After Cerebral Infarction

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STROKEAHA: April 18, 2013 Background and Purpose—The impact of asymptomatic coronary artery disease on the risk of major vascular events in patients with cerebral infarction is unknown. Methods—Four hundred five patients with acute cerebral infarction underwent carotid, femoral artery, thoracic, and abdominal aorta ultrasound examination. Of 342 patients with no known coronary heart disease, 315 underwent […]

Treatment with statins and ischemic stroke severity

Neurology: April 17, 2013 Objective: To examine the effects of pretreatment with statins at high doses (40 mg of rosuvastatin or 80 mg of any other statin) and low to moderate doses (<40 mg of rosuvastatin or <80 mg of any other statin) on ischemic stroke (IS) severity in clinical practice. Methods: Observational study of IS admissions to […]

Many Neuroscience Studies May Be Based on Bad Statistics

WIRED: April 15, 2013 The fields of psychology and cognitive neuroscience have had some rough sledding in recent years. The bumps have come from high-profile fraudsters, concerns about  findings that can’t be replicated, and criticism from within the scientific ranks about shoddy statistics. A new study adds to these woes, suggesting that a wide range of neuroscience studies lack the statistical […]

Meeting the ambition of measuring the quality of hospitals’ stroke care using routinely collected administrative data: a feasibility study

Int J Qual Health Care: April 12, 2013 Objective To examine the potential for using routinely collected administrative data to compare the quality and safety of stroke care at a hospital level, including evaluating any bias due to variations in coding practice. Design A retrospective cohort study of English hospitals’ performance against six process and outcome indicators covering […]

Standard of practice: embolization of ruptured and unruptured intracranial aneurysms

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J NeuroIntervent Surgery: April 10, 2013 Since its inception, coil embolization of cerebral aneurysms was designed and approved by the US Food and Drug Administration for aneurysms considered to be high risk for microsurgical clip ligation, but it is now increasingly considered as the first line of treatment. The techniques for endovascular aneurysm treatment have […]

Relationships between brain and body temperature, clinical and imaging outcomes after ischemic stroke

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Journal of Cerebral Blood Flow & Metabolism: April 10, 2013 Pyrexia soon after stroke is associated with severe stroke and poor functional outcome. Few studies have assessed brain temperature after stroke in patients, so little is known of its associations with body temperature, stroke severity, or outcome. We measured temperatures in ischemic and normal-appearing brain […]

Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block

Journal of Cerebral Blood Flow & Metabolism: April 10, 2013 Transglutaminases (TGs) are multifunctional, calcium-dependent enzymes that have been recently implicated in stroke pathophysiology. Classically, these enzymes are thought to participate in cell injury and death in chronic neurodegenerative conditions via their ability to catalyze covalent, nondegradable crosslinks between proteins or to incorporate polyamines into protein […]

Ozone is associated with cardiopulmonary and stroke emergency hospital visits in Reykjavik, Iceland 2003–2009

Environmental Health: April 8, 2013 Background Air pollution exposure is associated with hospital admissions and emergency room visits for cardiopulmonary disease and stroke. Iceland’s capital area, Reykjavik, has generally low air pollution levels, but traffic and natural sources contribute to pollution levels. The objective of this study was to investigate temporal associations between emergency hospital visits […]

Spinal ischemic stroke following dialysis: clinical and radiologic findings

Neurology: January 30, 2013 Spinal cord ischemia (SCI) is a relatively common cause of noncompressive myelopathy.1 SCI frequently involves the thoracic or lumbar cord manifesting as acute painful paraparesis but may also involve the posterior columns and autonomic fibers. Read more

ASTRAL Score Predicts 5-Year Dependence and Mortality in Acute Ischemic Stroke

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​STROKEAHA: April 4, 2013 Background and Purpose—The ASTRAL score was externally validated showing remarkable consistency on 3-month outcome prognosis in patients with acute ischemic stroke. The present study aimed to evaluate ASTRAL score’s prognostic accuracy to predict 5-year outcome. Methods—All consecutive patients with acute ischemic stroke registered in the Athens Stroke Registry between January 1, 1998, […]

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