Genotype-Guided vs Clinical Dosing of Warfarin and Its Analogues

Clinical Trials Saturday, July 5th, 2014

JAMA Intern Med.:  June 16, 2014

Importance  Significant variations in dose requirements of warfarin and its analogues (acenocoumarol and phenprocoumon) make selecting the appropriate dose for an individual patient difficult. Genetic factors account for approximately one-third of the variation in dose requirement. The clinical usefulness of genotype-guided dosing of warfarin has been previously assessed in randomized clinical trials that were limited by lack of power and inconsistent results.

Objective  To compare genotype-guided initial dosing of warfarin and its analogues with clinical dosing protocols.

Data Sources and Study Selection  MEDLINE (inception to December 31, 2013), EMBASE (inception to December 31, 2013), and the Cochrane Library Central Register of Controlled Trials (inception to December 31, 2013) were searched for randomized clinical trials comparing genotype-guided warfarin dosing vs clinical dosing for adults with indications for anticoagulation. Read More

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