The role of statin therapy in the prevention of atrial fibrillation: a meta-analysis of randomized controlled trials
Clinical Trials Monday, October 22nd, 2012John Wiley & Sons, Inc.: OCT 9, 2012
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
• Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia, and AF is associated with relatively higher all-cause mortality in both men and women.
• However, there are limited treatment options for AF.
• Statins are hypothesized to have a benefit against arrhythmias in addition to well-established secondary prevention benefit for atherosclerotic coronary artery disease, yet the data are inconsistent
WHAT THIS STUDY ADDS
• Statin therapy was significantly associated with a decreased risk of incidence or recurrence of AF.
• The benefit of statin therapy seemed more markedly in secondary prevention than primary prevention.
• These results provided some evidence for the benefit of statins beyond their lipid-lowering activity
AIMS The use of statins has been suggested to protect against atrial fibrillation (AF) in some clinical observational and experimental studies but has remained inadequately explored. This study was designed to examine whether statins can reduce the risk of AF. Read more
