Clinical Trials
Thursday, March 22nd, 2012
The New England Journal of Medicine: March 22, 2012. BACKGROUND Intravenous alteplase is the only approved treatment for acute ischemic stroke. Tenecteplase, a genetically engineered mutant tissue plasminogen activator, is an alternative thrombolytic agent. METHODS In this phase 2B trial, we randomly assigned 75 patients to receive alteplase (0.9 mg per kilogram of body weight) or […]
Clinical Trials
Thursday, March 22nd, 2012
Bmj.com: March 20, 2012. A major phase III clinical trial of mild hypothermia to treat stroke patients by cooling the brain will be launched later this year after the consortium involved secured funding of some €11m (£9.2m; $14.5m) from the European Commission’s research programme. Read More
Clinical Trials
Thursday, March 22nd, 2012
Stroke.ahajournals.org: March 15, 2012. Choice of Primary Outcome Measure Abstract Background and Purpose—The diversity of available outcome measures for acute stroke trials is challenging and implies that the scales may be imperfect. To assist researchers planning trials and to aid interpretation, this article reviews and makes recommendations on the available choices of scales. The aim is […]
Clinical Trials
Thursday, March 22nd, 2012
Stroke.ahajournals.org: March 15, 2012. Abstract Common outcome scales in acute stroke trials are ordered categorical or pseudocontinuous in structure but most have been analyzed as binary measures. The use of fixed dichotomous analysis of ordered categorical outcomes after stroke (such as the modified Rankin Scale) is rarely the most statistically efficient approach and usually requires a […]
Clinical Trials
Thursday, March 22nd, 2012
Science Direct: Kate M. O’Dell, PharmD, BCPS, March 12, 2012. Background Warfarin had been the only oral anticoagulant for stroke prevention in patients with atrial fibrillation (AF) for decades. Direct thrombin inhibitors and factor Xa inhibitors are new anticoagulants recently approved for prevention of stroke or systemic embolism in patients with AF. Objective The aim of […]
Therapies
Thursday, March 22nd, 2012
Reuters: By Anna Yukhananov, Wed Mar 21, 2012 12:38pm EDT. * Stent meant to unblock arteries in brain * NIH-funded study showed it did more harm than drugs * Watchdog group calls for withdrawal * FDA advisers to discuss stent on Friday WASHINGTON, March 21 (Reuters) – U.S. regulators on Wednesday questioned whether they should ask Stryker […]
Therapies
Thursday, March 22nd, 2012
Crc.ahajournals: March 19, 2012. Abstract Warfarin has been in clinical use for nearly 60 years, and in 2010 there were over 25 million prescriptions for warfarin in the U.S. While warfarin is highly efficacious, it has a narrow therapeutic window to achieve desired anticoagulation without excess risk of bleeding. Anticoagulation status is monitored with the International […]
Therapies
Thursday, March 22nd, 2012
Washington Post: By Lenny Bernstein, Published: March 19, 2012. Kris Brott was more amazed than alarmed when her tongue suddenly seemed to turn upside down in her mouth. She was in the office at Quince Orchard High School in Gaithersburg, dropping off a check for her son’s baseball team, when she suddenly found herself quite literally tongue-tied. Her […]
Therapies
Thursday, March 22nd, 2012
Medicalxpress: in Cardiology March 16, 2012. Copenhagen, 16 March 2012: Stroke survivors who like art have a significantly higher quality of life than those who do not, according to new research. Patients who appreciated music, painting and theatre recovered better from their stroke than patients who did not. Stroke is the third cause of death in the western […]
Therapies
Thursday, March 22nd, 2012
The Cochrane Library: MARCH 14, 2012. Abstract Background Mirror therapy is used to improve motor function after stroke. During mirror therapy, a mirror is placed in the patient’s midsagittal plane, thus reflecting movements of the non-paretic side as if it were the affected side. Objectives To summarise the effectiveness of mirror therapy for improving motor function, activities […]
