Knowledge of heart attack and stroke symptomology: a cross-sectional comparison of rural and non-rural US adults

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Biomedcentral.com: April 10, 2012. Understanding the signs and symptoms of heart attacks and strokes are important not only in saving lives, but also in preserving quality of life. Findings from recent research have yielded that the prevalence of cardiovascular disease risk factors are higher in rural populations, suggesting that adults living in rural locales may be […]

Comparison of the Framingham and Reynolds Risk Scores for Global Cardiovascular Risk Prediction in the Multiethnic Women’s Health Initiative

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Circ.ahajournals.org: April 10, 2012. Background—Framingham-based and Reynolds Risk scores for cardiovascular disease (CVD) prediction have not been directly compared in an independent validation cohort. Methods and Results—We selected a case-cohort sample of the multiethnic Women’s Health Initiative Observational Cohort, comprising 1722 cases of major CVD (752 myocardial infarctions, 754 ischemic strokes, and 216 other CVD […]

Efficacy of Omega-3 Fatty Acid Supplements (Eicosapentaenoic Acid and Docosahexaenoic Acid) in the Secondary Prevention of Cardiovascular Disease

Archinte.ama-assn.org: April 9, 2012. A Meta-analysis of Randomized, Double-blind, Placebo-Controlled Trials Sang Mi Kwak, MD; Seung-Kwon Myung, MD; Young Jae Lee, MD, MS; Hong Gwan Seo, MD, PhD; for the Korean Meta-analysis Study Group Arch Intern Med. Published online April 9, 2012. doi:10.1001/archinternmed.2012.262 Background  Although previous randomized, double-blind, placebo-controlled trials reported the efficacy of omega-3 fatty acid supplements in the secondary […]

Stroke Risk May be Elevated Among Smokers of Mentholated Cigarettes

Newsatjama.jama.com: Women’s Health — Bridget M. Kuehn @ 3:06 pm, April 9, 2012. Smoking mentholated cigarettes may increase stroke risk in certain individuals, a study published today in theArchives of Internal Medicine suggests. Many questions remain about the health effects of smoking mentholated vs nonmentholated cigarettes. Some evidence suggests that smoking mentholated cigarettes increases the likelihood of developing a smoking habit. Other […]

Baseline Cardiovascular Risk Predicts Subsequent Changes in Resting Brain Function

Stroke.ahajournals.org: April 5, 2012. Background and Purpose—The Framingham Heart Study group cardiovascular disease risk profile (FCRP) score was used to assess the relationship between baseline cardiovascular risk and subsequent changes in resting state cerebral blood flow (CBF) in cognitively normal older participants from the Baltimore Longitudinal Study of Aging. Methods—Ninty-seven cognitively normal participants underwent annual […]

Whole Genome Expression Differences in Human Left and Right Atria Ascertained by RNA-Sequencing

Circgenetics.ahajournals.org: Aril 3, 2012. Background—The left and right atria have different susceptibilities towards developing arrhythmias, with left atrial arrhythmias more commonly observed. To understand the molecular basis for such differences, we catalogued miRNA and mRNA expression differences by next generation sequencing. Methods and Results—Four human left-right atrial pairs were subjected to whole-genome expression analyses via […]

Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: a randomised controlled trial

The Lancet Neurology, Early Online Publication, April 11, 2012. Background Only 2—5% of patients who have a stroke receive thrombolytic treatment, mainly because of delay in reaching the hospital. We aimed to assess the efficacy of a new approach of diagnosis and treatment starting at the emergency site, rather than after hospital arrival, in reducing […]

Intracranial Hemorrhage in Atrial Fibrillation Patients During Anticoagulation With Warfarin or Dabigatran

Stroke.ahajournals.org: April 5, 2012. Background and Purpose—Intracranial hemorrhage is the most devastating complication of anticoagulation. Outcomes associated with different sites of intracranial bleeding occurring with warfarin versus dabigatran have not been defined. Methods—Analysis of 18 113 participants with atrial fibrillation in the Randomized Evaluation of Long-term anticoagulant therapY (RE-LY) trial assigned to adjusted-dose warfarin (target international […]

Treatment With B Vitamins and Incidence of Cancer in Patients With Previous Stroke or Transient Ischemic Attack

Stroke.ahajournals.org: April 3, 2012. Background and Purpose—To determine the effect of B vitamin treatment on the incidence of cancer among patients with stroke or transient ischemic attack. Methods—A total of 8164 patients with recent stroke or transient ischemic attack were randomly allocated to double-blind treatment with 1 tablet daily of placebo or B vitamins (2 […]

Vascular Occlusion Enables Selecting Acute Ischemic Stroke Patients for Treatment With Desmoteplase

Stroke.ahajournals.org: April 3, 2012. Background and Purpose—Desmoteplase is a novel and highly fibrin-specific thrombolytic agent. Evidence of safety and efficacy was obtained in 2 phase II trials (Desmoteplase In Acute Ischemic Stroke [DIAS] and Desmoteplase for Acute Ischemic Stroke [DEDAS]). The DIAS-2 phase III trial did not replicate the positive phase II efficacy findings. Post hoc […]

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