Trends in CVD and Stroke Mortality

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Networking.americanheart.org: 5/24/2012. Heart diseases and stroke, the number 1 and 4 leading causes of death in the United States, kill over 810,000 people every year. Even though death rates have been decreasing, disparities in the rate of decline among subpopulations and resulting disabilities from heart diseases and stroke are still issues to be addressed. Achieving ideal […]

Ideal Cardiovascular Health Predicts Lower Risks of Myocardial Infarction, Stroke, and Vascular Death across Whites, Blacks and Hispanics: the Northern Manhattan Study

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Circ.ahajournals.org: 5/22/2012. Background—Evidence regarding the relationship of cardiovascular health (CVH) defined by the American Heart Association (AHA) and specific cardiovascular outcomes is lacking, particularly among Hispanics. This study sought to evaluate the relationship between the number of ideal CVH metrics and cardiovascular risk, overall and by event subtype, in a multiethnic community-based prospective cohort. Methods and […]

Posttraumatic Stress Disorder and Adherence to Medications in Survivors of Strokes and Transient Ischemic Attacks

Stroke.ahajournals.org: May 22, 2012. Background and Purpose—Posttraumatic stress disorder (PTSD) can be triggered by life-threatening medical events such as strokes and transient ischemic attacks (TIAs). Little is known regarding how PTSD triggered by medical events affects patients’ adherence to medications. Methods—We surveyed 535 participants, age ≥40 years old, who had at least 1 stroke or TIA […]

The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial

The Lancet, Early Online Publication, 23 May 201. Background Thrombolysis is of net benefit in patients with acute ischaemic stroke, who are younger than 80 years of age and are treated within 4·5 h of onset. The third International Stroke Trial (IST-3) sought to determine whether a wider range of patients might benefit up to […]

Clinical Trials 101

Stroke.org: 5/22/2012. Should you participate? What to know before you sign up Patients interested in new and alternative medical therapies for stroke treatment often look into clinical research opportunities. In fact, post-stroke clinical trials are seeing increased participation each year. During a clinical trial, experimental medicines and medical devices undergo a multi-phase, Food and Drug Administration […]

Feasibility of Prehospital Teleconsultation in Acute Stroke – A Pilot Study in Clinical Routine

Plosone.org: 5/18/2012. Inter-hospital teleconsultation improves stroke care. To transfer this concept into the emergency medical service (EMS), the feasibility and effects of prehospital teleconsultation were investigated. Methodology/Principal Findings Teleconsultation enabling audio communication, real-time video streaming, vital data and still picture transmission was conducted between an ambulance and a teleconsultation center. Pre-notification of the hospital was carried […]

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

The Lancet, Early Online Publication, 17 May 2012. Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain. Methods This meta-analysis included individual participant data from 22 trials of statin versus control (n=134537; mean LDL cholesterol difference 1.08 mmol/L; median follow-up 4.8 years) […]

Recent Clinical Trials in Atrial Fibrillation in Hypertensive Patients

springerlink.com:  5/11/2012. Athanasios J. Manolis, Manolis S. Kallistratos and Leonidas E. Poulimenos Current Hypertension Reports, Online First™, 11 May 2012 Read More

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

The Lancet, Early Online Publication, 23 May 2012. Recombinant tissue plasminogen activator (rt-PA, alteplase) improved functional outcome in patients treated soon after acute ischaemic stroke in randomised trials, but licensing is restrictive and use varies widely. The IST-3 trial adds substantial new data. We therefore assessed all the evidence from randomised trials for rt-PA in […]

Inpatient statin use predicts improved ischemic stroke discharge disposition

Neurology.org: 5/22/2012. Objective: To determine whether statin use is associated with improved discharge disposition after ischemic stroke. Methods: We used generalized ordinal logistic regression to analyze discharge disposition among 12,689 patients with ischemic stroke over a 7-year period at 17 hospitals in an integrated care delivery system. We also analyzed treatment patterns by hospital to control for the […]

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