Regional Variation in Recommended Treatments for Ischemic Stroke and TIA

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Get With the Guidelines-Stroke 2003–2010 Stroke.ahajournals.org: May 15, 2012. Background and Purpose—Secondary stroke prevention treatments vary in different regions of the US. We determined the degree to which guideline-recommended stroke treatments vary by region for patients treated at hospitals participating in a voluntary national quality improvement program, Get With The Guidelines-Stroke. Methods—Receipt of 8 guideline-recommended treatments […]

Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage

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A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association Stroke.ahajournals.org: May 3, 2012. Purpose—The aim of this guideline is to present current and comprehensive recommendations for the diagnosis and treatment of aneurysmal subarachnoid hemorrhage (aSAH). Methods—A formal literature search of MEDLINE (November 1, 2006, through May 1, 2010) was performed. Data were synthesized […]

Hospitalization for Stroke in U.S. Hospitals, 1989–2009

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Cdc.gov: Number 95, Margaret Jean Hall, Ph.D.; Shaleah Levant, M.P.H.; and Carol J. DeFrances, Ph.D., May 2012. The rate of hospitalization for stroke (cerebrovascular disease) per 10,000 population increased from 32.4 in 1989 to 34.9 in 1999, and then decreased to 31.8 in 2009. About 800,000 hospitalizations for stroke occurred in 1989 and almost 1 million in 1999 […]

The relationship between executive dysfunction and post-stroke mortality: a population-based cohort study

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Bmjopen.bmj.com: May 9th, 2012. Objectives To study the associations of pre-stroke cognitive performance with mortality after first-ever stroke or transient ischaemic attack (TIA). Design A prospective cohort study. Setting and participants In participants having first-ever stroke or TIA during up to 14 years of post-test follow-up (n=155), we investigated the associations of pre-stroke variables and cognitive test results with […]

Speedier treatment and better outcomes for high volume stroke centers

Medicalxpress.com: May 9, 2012 in Surgery Treatment is faster and outcomes are better at stroke centres dealing with a high volume of patients, finds research published online in the Journal of NeuroInterventional Surgery.   The authors base their findings on 442 patients treated with endovascular therapy—clot busting treatment provided inside the brain via a catheter without the need for surgery—at […]

Intracranial Carotid Artery Atherosclerosis

Stroke.ahajournals.org: May 8, 2012. Background and Purpose—Intracranial atherosclerosis is worldwide one of the leading causes of stroke. However, surprisingly little is known about its prevalence and risk factors in a community-dwelling population of white descent. In this study, we determined the prevalence and investigated risk factors of intracranial internal carotid artery calcification (ICAC) as a marker […]

Predicting the Risk of Symptomatic Intracerebral Hemorrhage in Ischemic Stroke Treated With Intravenous Alteplase

Stroke.ahajournals.org: March 22, 2012. Background and Purpose—Symptomatic intracerebral hemorrhage (SICH) is a serious complication in patients with acute ischemic stroke treated with intravenous thrombolysis. We aimed to develop a clinical score that can easily be applied to predict the risk of SICH. Methods—We analyzed data from 31 627 patients treated with intravenous alteplase enrolled in the […]

Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial

The Lancet Neurology, Early Online Publication, 8 May 2012. In the ARISTOTLE trial, the rate of stroke or systemic embolism was reduced by apixaban compared with warfarin in patients with atrial fibrillation (AF). Patients with AF and previous stroke or transient ischaemic attack (TIA) have a high risk of stroke. We therefore aimed to assess […]

Rethinking Research Ethics: The Case of Postmarketing Trials

Sciencemag.org: Science 4 May 2012: From the Nuremberg Code onward, the core mission of human subjects research ethics has been to protect study participants from infringements motivated by a zeal for medical progress. However, with individuals, clinicians, and policymakers increasingly dependent on scientific information for decision-making and with vast social resources invested in developing and utilizing the […]

Aligning Cultural and Financial Incentives for Clinical Trials

Iom.edu: May 4, 2012. Participant in the activities of the Institute of Medicine Forum on Drug Discovery, Development, and Translation. This commentary was developed following the Forum’s November 2011 workshop to envision a transformed U.S. clinical trials enterprise. Note: The views expressed in commentaries are those of the authors and not necessarily of the authors’ organizations or […]

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