Association of Prediabetes and Diabetes With Stroke Symptoms

The Reasons for Geographic And Racial Differences in Stroke (REGARDS) study Care.diabetesjournals.org Diabetes Care June 14, 2012. Stroke symptoms among individuals reporting no physician diagnosis of stroke are associated with an increased risk of future stroke. Few studies have assessed whether individuals with diabetes or prediabetes, but no physician diagnosis of stroke, have an increased prevalence of […]

Prevention Council issues action plan to promote wellness

Hhs.gov: June 13, 2012. Release of the implementation plan for the Nation’s first health and wellness road map Surgeon General Regina M. Benjamin today announced the release of the National Prevention Council Action Plan, which aims to increase the number of Americans who are healthy at every stage of life. The Action Plan is the next […]

Glycine Exerts Dual Roles in Ischemic Injury Through Distinct Mechanisms

Stroke.ahajournals.org: June 12, 2012. We characterized the differential effects of glycine at different levels in the induction of postischemic long-term potentiation, as well as in the neuronal damage induced by focal ischemia. Methods—Whole-cell patch clamp recordings were obtained from rat hippocampal slice preparations. In vitro ischemia and postischemic long-term potentiation were induced by oxygen and […]

Short-term versus long-term antiarrhythmic drug treatment after cardioversion of atrial fibrillation (Flec-SL): a prospective, randomised, open-label, blinded endpoint assessment trial

Antiarrhythmic drugs prolong the atrial action potential and refractory period, and thereby prevent recurrent atrial fibrillation after cardioversion. The atrial action potential normalises after 2—4 weeks of sinus rhythm, suggesting that antiarrhythmic drugs might not be needed beyond that period. Therefore, we investigated whether short-term antiarrhythmic drug treatment after cardioversion is non-inferior to long-term treatment. […]

Stroke patients see ‘improvements’ after stem cell trial

Bbc.co.uk: By Eleanor BradfordBBC Scotland Health Correspondent. The first patients to take part in a clinical trial of a stem cell treatment for stroke have seen reductions in their disability, according to doctors. Six patients in the west of Scotland had human stem cells inserted close to the damaged part of their brain. After receiving the […]

Intensive Versus Subcutaneous Insulin in Patients With Hyperacute Stroke

Stroke.ahajournals.org: June 14, 2012. Intensive insulin therapy (IIT) has not yet proven its efficacy on stroke prognosis or in the reduction of MRI infarct growth. The INSULINFARCT study aims at determining in patients with hyperacute stroke whether IIT, with a better control of poststroke hyperglycemia, would reduce subsequent MRI infarct growth than usual care with subcutaneous […]

Outcome After Mobilization Within 24 Hours of Acute Stroke

Stroke.ahajournals.org: June 14, 2012 A Randomized Controlled Trial Very early mobilization (VEM) is considered to contribute to the beneficial effects of stroke units, but there are uncertainties regarding the optimal time to start mobilization. We hypothesized that VEM within 24 hours after admittance to the hospital would reduce poor outcome 3 months poststroke compared with […]

Peri-Procedural Bleeding and Thromboembolic Events with Dabigatran Compared to Warfarin: Results from the RE-LY Randomized Trial

Circ.ahajournals.org: June 14, 2012. Dabigatran reduces ischemic stroke compared to warfarin; however, given the lack of antidote, there is concern that it might increase bleeding when surgery or invasive procedures are required. Methods and Results—The current analysis was undertaken to compare the peri-procedural bleeding risk of patients in the RE-LY trial treated with dabigatran and warfarin. […]

Clinical Outcomes Using a Platelet Function-Guided Approach for Secondary Prevention in Patients With Ischemic Stroke or Transient Ischemic Attack

Stroke.ahajournals.org: June 19, 2012. Antiplatelet therapy nonresponse is associated with worse clinical outcomes. We studied the clinical outcomes associated with platelet function-guided modifications in antiplatelet therapy in patients with ischemic stroke or transient ischemic attack. Methods—From January 2005 to August 2007, 324 patients with ischemic stroke underwent platelet function testing using platelet aggregometry. Aspirin nonresponse was […]

Effects of Repetitive Transcranial Magnetic Stimulation on Motor Functions in Patients With Stroke

Stroke.ahajournals.org: June 19, 2012. The purpose of this study was to perform a meta-analysis of studies that investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on upper limb motor function in patients with stroke. Methods—We searched for randomized controlled trials published between January 1990 and October 2011 in PubMed, Medline, Cochrane, and CINAHL using the […]

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