News
Thursday, July 12th, 2012
Stroke.ahajournals.org: July 7, 2012. We examined the association between major perioperative hemorrhage and stroke or myocardial infarction among adults who underwent surgery from 2005 through 2009 at centers participating in the National Surgical Quality Improvement Program. We excluded patients with emergent, trauma-related, transplantation, cardiac, or neurological operations. Major hemorrhage was defined as bleeding necessitating transfusion […]
News
Thursday, July 12th, 2012
Stroke.ahajournals.org: July 5, 2012. Background and Purpose—Initial stroke severity is one of the strongest predictors of eventual stroke outcome. However, predictors of initial stroke severity have not been well-described within a population. We hypothesized that poorer patients would have a higher initial stroke severity on presentation to medical attention. Methods—We identified all cases of hospital-ascertained […]
News
Thursday, July 12th, 2012
Stroke.ahajournals.org: July 3, 2012. Background and Purpose—Aside from the primary motor cortex, the corticospinal tract (CST) also receives fibers from dorsal and ventral premotor cortices and supplementary motor area, all of which might potentially contribute to motor function after stroke. We sought to quantify the microstructural integrity of CST originating from the hand representations in these […]
News
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 7/3/12. The Essen stroke risk score is widely applied to predict the risk of recurrent ischemic stroke. We developed a modified Essen stroke risk score and validated it using a large prospective Effective Vascular Event REduction after STroke (EVEREST) registry including 3588 patients with ischemic stroke in Japan. Patients with cardioembolic stroke were excluded, and […]
News
Wednesday, July 11th, 2012
Stroke.ahajournals.org: June 28, 2012. Evidence is emerging that inflammation plays a key role in the pathophysiology of ischemic stroke (IS). The aim of this study was to investigate whether genetic variation in the interleukin-1α, interleukin-1β, and interleukin-1 receptor antagonist genes (IL1A, IL1B, and IL1RN) is associated with IS and/or any etiologic subtype of IS. Methods—Twelve tagSNPs were analyzed […]
News
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 6/19/12. Animal models of stroke contribute to the development of better stroke prevention and treatment through studies investigating the pathophysiology of different stroke subtypes and by testing promising treatments before trials in humans. There are two broad types of animal models: those in which stroke is induced through artificial means, modeling the consequences of a […]
News
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 5/9/12. Cardiorespiratory fitness programs are increasingly used in stroke rehabilitation. Maximal oxygen uptake is the gold standard measurement of cardiorespiratory fitness; however, no recent publications have collated evidence about maximal oxygen uptake levels following stroke. We therefore performed a systematic review of maximal oxygen uptake in stroke survivors, aiming to observe changes in levels over […]
News
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 5/9/12. Consecutive patients were interviewed about life events exposure (e.g. bereavement) using the Interview for Recent Life Events. Using a case-crossover approach, life events exposure within one month of stroke onset (hazard period) was compared with exposure during five control periods of one month preceding the hazard period. Similarly, life events exposure within one week […]
Therapies
Wednesday, July 11th, 2012
Stroke.ahajournals.org: June 28, 2012. Conflicting data exist regarding outcomes after intra-arterial therapy (IAT) in elderly stroke patients. We compare safety and clinical outcomes of multimodal IAT in elderly versus nonelderly patients and investigate differences in baseline health and disability as possible explanatory factors. Methods—Data from a prospectively collected institutional IAT database were analyzed comparing elderly (80 […]
Therapies
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 6/19/12. Many advances have been achieved in terms of understanding the molecular and cellular mechanisms of ischemic stroke. But thus far, clinically effective neuroprotectants remain elusive. In this minireview, we summarize the basics of ischemic cascades after stroke, covering neuronal death mechanisms, white matter pathophysiology, and inflammation with an emphasis on microglia. Translating promising mechanistic […]
