Therapies
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 6/19/12. The main driving force behind the assessment of novel pharmacological agents in animal models of stroke is to deliver new drugs to treat the human disease rather than to increase knowledge of stroke pathophysiology. There are numerous animal models of the ischaemic process and it appears that the same processes operate in humans. Yet, […]
Therapies
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 5/28/12. Infections are common complications in patients with acute ischemic stroke; however, the pathophysiology of the stroke-induced immunodepression is still under debate. Although it has been shown that increased mortality and longer hospital stay are associated with the presence of poststroke infections, it remains unclear if early poststroke infections occurring in the first seven-days have […]
Therapies
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 5/9/12. Our cohort included 1398 consecutive ischemic stroke patients treated with intravenous thrombolysis at the Helsinki University Central Hospital, years 1995–2010. We analyzed the patients according to baseline National Institutes of Health Stroke Scale: ≤2, 3–4, 5–6, and >6. In our institution, visualization of an artery occlusion or perfusion deficit is required for thrombolysis with […]
Clinical Trials
Wednesday, July 11th, 2012
Iospress.metapress.com: 7/5/12. Purpose: Transcranial direct current stimulation (tDCS) combined with swallowing training might improve swallowing function in patients with post-stroke dysphagia. We investigate the effects of transcranial direct current stimulation (tDCS) combined with swallowing training on post-stroke dysphagia. Methods: Sixteen patients with post-stroke dysphagia, diagnosed using video fluoroscopic swallowing (VFSS), were randomly assigned into two groups: […]
Clinical Trials
Wednesday, July 11th, 2012
Brain.oxfordjournals.org: July 2, 2012. Hemispatial neglect following right-hemisphere stroke is a common and disabling disorder, for which there is currently no effective pharmacological treatment. Dopamine agonists have been shown to play a role in selective attention and working memory, two core cognitive components of neglect. Here, we investigated whether the dopamine agonist rotigotine would have a […]
Clinical Trials
Wednesday, July 11th, 2012
News-medical.net: Published on July 2, 2012 at 11:45 PM: A new approach to testing medical treatment options could ensure that more patients get the most beneficial treatment for them – but still yield valuable research results that stand up to scientific scrutiny. The approach tries to overcome a huge chicken-and-egg problem in medical research: Not enough […]
Clinical Trials
Wednesday, July 11th, 2012
Ctj.sagepub.com: July 2, 2012. There is a growing appreciation that our current approach to clinical research leaves important gaps in evidence from the perspective of patients, clinicians, and payers wishing to make evidence-based clinical and health policy decisions. This has been a major driver in the rapid increase in interest in comparative effectiveness research (CER), which […]
Clinical Trials
Wednesday, July 11th, 2012
Onlinelibrary.wiley.com: 6/19/12. The mortality and morbidity associated with stroke makes the development of new drugs a research priority. Recent unsuccessful clinical trials have reduced enthusiasm for the development of neuroprotective drugs. Here, we use empirical evidence derived from systematic reviews of stroke drug development to identify stages of drug development which might be improved. We then […]
Atrial Fibrillation
Wednesday, July 11th, 2012
Circep.ahajournals.org: June 30, 2012 We sought to determine the relationship between the size of the left atrial (LA) isolated surface area (ISA) after pulmonary vein antrum isolation (PVAI) for paroxysmal atrial fibrillation (AF) and rhythm outcome during a 12-month follow-up. Methods and Results—101 consecutive patients with paroxysmal AF (mean age 59±11 years, median AF history 36 […]
Atrial Fibrillation
Wednesday, July 11th, 2012
Sciencedirect.com: 6/2212. Computational electrophysiology has proven useful to investigate the mechanisms of cardiac arrhythmias at various spatial scales, from isolated myocytes to the whole heart. This article reviews how mathematical modeling has aided our understanding of human atrial myocyte electrophysiology to study the contribution of structural and electrical remodeling to human atrial fibrillation. Potential new avenues […]
