Female risk factors for subarachnoid hemorrhage A systematic review

Neurology.org: September 5, 2012 To systematically review the literature on female risk factors and risk of SAH. Methods: We searched Medline and EMBASE for articles published between January 1985 and July 2011. For all studies fulfilling the predefined criteria, we obtained risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) for female risk factors. […]

National Trends in Utilization and Outcomes of Endovascular Treatment of Acute Ischemic Stroke Patients in the Mechanical Thrombectomy Era

Stroke.ahajournals.org: 9/11/12 Because several new devices for mechanical thrombectomy have become available, the outcomes of patients undergoing endovascular treatment for acute ischemic stroke are expected to improve in the United States. We performed this analysis to evaluate trends in utilization of endovascular treatment and associated rates of death and disability among acute ischemic stroke patients over […]

Endovascular therapy yields significantly superior outcomes for large vessel occlusions compared with intravenous thrombolysis: is it time to randomize?

Jnis.bmj.com:  July 28, 2012 We compared outcomes between endovascular (EV) therapy and intravenous (IV) thrombolysis in large vessel strokes. Methods 223 patients who had received either IV (n=100) or EV (n=123) therapy were analyzed. Only patients with strokes involving the internal carotid artery terminus (ICA-T, n=45), the middle cerebral artery (M1, n=107) or the bifurcation branches (M2, […]

Multimodal endovascular management of acute ischemic stroke in patients over 75 years old is safe and effective

http://jnis.bmj.com 7/11/12 Greater attention has been directed to endovascular recanalization of acute ischemic stroke in septuagenarians and above. Technique A retrospective chart review was conducted to include patients treated for acute ischemic stroke from 2006 to 2012. All patients underwent initial neurological assessment and non-contrast head CT. Patients treated from 2009 to 2012 additionally received emergent CT […]

Single Ring Posterior Left Atrial (Box) Isolation Results in a Different Mode of Recurrence Compared to Wide Antral Pulmonary Vein Isolation on Long Term Follow Up: Longer AF Free Survival Time but Similar Survival Time Free of Any Atrial Arrhythmia

Circep.ahajournals.org: 9/12/12 isolation of the pulmonary veins and posterior left atrium with a single ring of radiofrequency lesions (SRI) may result in fewer atrial fibrillation (AF) recurrences than wide antral pulmonary vein isolation (WAI) by abolishing extravenous AF triggers. The effect of mitral isthmus line (MIL) ablation on outcomes after SRI has not previously been assessed. […]

Impact of operator and site experience on outcomes after angioplasty and stenting in the SAMMPRIS trial

Jnis.bmj.com: 9/12/12 To investigate the relationship between physician and site experience and the risk of 30 day hemorrhagic and ischemic strokes in the stenting arm of the Stenting and Aggressive Medical Management for the Prevention of Recurrent Ischemic Stroke (SAMMPRIS) trial. Methods Study records and an investigator survey were examined for physician and site related factors, including: […]

Smartphone Teleradiology Application Is Successfully Incorporated Into a Telestroke Network Environment

Stroke.ahajournals.org: September 11, 2012 ResolutionMD mobile application runs on a Smartphone and affords vascular neurologists access to radiological images of patients with stroke from remote sites in the context of a telemedicine evaluation. Although reliability studies using this technology have been conducted in a controlled environment, this study is the first to incorporate it into a […]

Ethical Considerations in Studying Drug Safety — The Institute of Medicine Report

Nejm.org: September 6, 2012 The tumult arising from revelations of serious safety risks associated with widely prescribed drugs, including rosiglitazone (Avandia, GlaxoSmithKline), rofecoxib (Vioxx, Merck), and celecoxib (Celebrex, Pfizer), has led to widespread recognition that improvement is needed in our national system of ensuring drug safety. Notwithstanding federal legislation in 2007 that strengthened the authority of […]

Clinical Trial Data as a Public Good

Jama.jamanetwork.com: 9/6/12 Marc A. Rodwin, JD, PhD; John D. Abramson, MD, MS Knowledge of the benefits and risks of prescription drugs is based mainly on published reports of clinical trials, yet the medical literature may present an incomplete and potentially biased sample of clinical trials.1 Trials with positive results generally are published more frequently than studies that […]

Red Flag Raised On Offbeat Hearts

ScienceDaily (Sep. 7, 2012) — An estimated 2.5 million Americans suffer from irregular heartbeats-also known as atrial fibrillation. Baylor Health Care System is raising awareness about this often misunderstood, but potentially life changing cardiovascular condition whose incidence is on the rise and expected to more than double by 2050. “One of the biggest misconceptions about atrial […]

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