Atrial Fibrillation
Thursday, October 11th, 2012
Circ.ahajournals.org: 10/9/12 Background—Premature atrial contractions (PACs) are independent predictors of atrial fibrillation, stroke and death. However, little is known about PAC frequency in the general population and its association with other cardiovascular risk factors. Methods and Results—We performed a cross-sectional analysis among participants of the population-based Swiss cohort Study on Air Pollution and […]
Atrial Fibrillation
Thursday, October 11th, 2012
Plosone.org: 10/9/12 Apixaban was shown to be superior to adjusted-dose warfarin in preventing stroke or systemic embolism in patients with atrial fibrillation (AF) and at least one additional risk factor for stroke, and associated with reduced rates of hemorrhage. We sought to determine the cost-effectiveness of using apixaban for stroke prevention. Methods Based on the […]
Atrial Fibrillation
Thursday, October 11th, 2012
Content.onlinejacc.org 10/1/12 Objectives This study describes the 5-year efficacy of catheter ablation for long-standing persistent atrial fibrillation (LS-AF). Background Long-term outcome data after catheter ablation for LS-AF are limited. Methods Long-term follow-up of 56 months (range 49 to 67 months) was performed in 202 patients (age 61 ± 9 years) who underwent the sequential ablation strategy for symptomatic […]
Clinical Trials
Thursday, October 11th, 2012
Nih.gov: 10/10/12 A workshop sponsored by NIH’s National Institute of Neurological Disorders and Stroke (NINDS) has produced a set of consensus recommendations to improve the design and reporting of animal studies. By making animal studies easier to replicate and interpret, the workshop recommendations are expected to help funnel promising therapies to patients. Biomedical research involving […]
Clinical Trials
Thursday, October 11th, 2012
Thelancet.com: 10/8/12 Background Neuroprotection with NA-1 (Tat-NR2B9c), an inhibitor of postsynaptic density-95 protein, has been shown in a primate model of stroke. We assessed whether NA-1 could reduce ischaemic brain damage in human beings. Methods For this double-blind, randomised, controlled study, we enrolled patients aged 18 years or older who had a ruptured or unruptured […]
Clinical Trials
Thursday, October 11th, 2012
Thelancet.com: 10/6/12 Background The Solitaire Flow Restoration Device is a novel, self-expanding stent retriever designed to yield rapid flow restoration in acute cerebral ischaemia. We compared the efficacy and safety of Solitaire with the standard, predicate mechanical thrombectomy device, the Merci Retrieval System. Methods In this randomised, parallel-group, non-inferiority trial, we enrolled patients from 18 […]
Clinical Trials
Thursday, October 11th, 2012
Thelancet.com: 10/6/12 Background Present mechanical devices are unable to achieve recanalisation in up to 20—40% of large vessel occlusion strokes. We compared efficacy and safety of the Trevo Retriever, a new stent-like device, with its US Food and Drug Administration-cleared predecessor, the Merci Retriever. Methods In this open-label randomised controlled trial, we recruited patients at […]
Clinical Trials
Thursday, October 11th, 2012
Ns.umich.edu: 10/3/12 ANN ARBOR, Mich.—Large amounts of missing data in clinical trials can undermine the scientific credibility of the studies, according to a special report by an expert panel commissioned by the National Research Council. The panel, chaired by Roderick Little, the Richard D. Remington Collegiate Professor of Biostatistics at the University of Michigan School […]
Therapies
Thursday, October 11th, 2012
Nature.com: 10/10/12 Substantial experimental data and recent clinical evidence suggesting that tissue reperfusion is a better predictor of outcome after thrombolysis than recanalization necessitate that patency of microcirculation after recanalization should be reevaluated. If indeed microcirculatory blood flow cannot be sufficiently reinstituted despite complete recanalization as commonly observed in coronary circulation, it may be one […]
Therapies
Thursday, October 11th, 2012
Jnis.bmj.com: 10/6/12 Introduction A number of recent trials evaluating intra-arterial therapies for acute ischemic stroke have been completed. We present a review of prospective acute ischemic stroke trials reported in a peer-reviewed forum during the last 20 years to provide insight into the general direction of this rapidly evolving field. Methods Prospective trials evaluating acute stroke intra-arterial therapies […]
