Atrial Fibrillation
Thursday, November 22nd, 2012
AMA: 11/19/12 Background—Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death (SCD) and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of […]
Atrial Fibrillation
Thursday, November 22nd, 2012
Sciencedirect: 11/10 Statistical modeling of atrioventricular (AV) nodal function during atrial fibrillation (AF) is revisited for the purpose of defining model properties and improving parameter estimation. The characterization of AV nodal pathways is made more detailed and the number of pathways is now determined by the Bayesian information criterion, rather than just producing a probability as […]
Atrial Fibrillation
Thursday, November 22nd, 2012
AHA: 8/21/12 Background—Oral anticoagulants such as apixaban, dabigatran, and rivaroxaban are alternatives to warfarin for preventing events in patients with atrial fibrillation. Direct comparative studies between agents are unavailable. Our objective was to conduct an adjusted indirect comparison meta-analysis between new oral agents in atrial fibrillation. Methods and Results—We searched MEDLINE and Cochrane Central through […]
Clinical Trials
Thursday, November 22nd, 2012
AHA: 11/16/12 Background—Stroke occurs more commonly after carotid artery stenting than carotid endarterectomy. Details regarding stroke type, severity, and characteristics have not been previously reported. We describe the strokes occurring in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Methods and Results—CREST is a randomized, open-allocation, controlled trial with blinded endpoint adjudication. Stroke was a […]
Clinical Trials
Thursday, November 22nd, 2012
Trials Journal: 11/16/12 Non-inferiority and equivalence trials require tailored methodology and therefore adequate conduct and reporting is an ambitious task. The aim of our review was to assess whether the criteria recommended by the CONSORT extension were followed. Methods: We searched the Medline database and the Cochrane Central Register for reports of randomised non-inferiority and equivalence trials […]
Clinical Trials
Thursday, November 22nd, 2012
Plosone: 11/15/12 Authors of randomized trial reports seem to hold a variety of views regarding the relationship between missing outcome data (MOD) and intention to treat (ITT). The objectives of this study were to systematically investigate how authors of methodology articles define ITT in the presence of MOD, how they recommend handling MOD under ITT, and […]
Clinical Trials
Thursday, November 22nd, 2012
Plosone: 11/14/12 Since September 2005, the International Committee of Medical Journal Editors (ICMJE) has required that randomised controlled trials (RCTs) are prospectively registered in a publicly accessible database. After registration, a trial registration number (TRN) is assigned to each RCT, which should make it easier to identify future publications and cross-check published results with associated registry […]
Clinical Trials
Thursday, November 22nd, 2012
AHA: 11/13/12 Background and Purpose—To assess whether the combined analysis of all phase III trials of nonvitamin-K-antagonist (non-VKA) oral anticoagulants in patients with atrial fibrillation and previous stroke or transient ischemic attack shows a significant difference in efficacy or safety compared with warfarin. Methods—We searched PubMed until May 31, 2012, for randomized clinical trials using the […]
Therapies
Thursday, November 22nd, 2012
AHA: 11/15/12 Background and Purpose—The rationale for recanalization therapy in acute ischemic stroke is to preserve brain through penumbral salvage and thus improve clinical outcomes. We sought to determine the relationship between recanalization, clinical outcomes, and final infarct volumes in acute ischemic stroke patients presenting with middle cerebral artery occlusion who underwent endovascular therapy and […]
Guidelines, News
Thursday, November 22nd, 2012
JACC: 11/20/12 The medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease. When properly applied, expert analysis of available data on the benefits and risks of these therapies and procedures can improve the quality of care, optimize patient outcomes, and favorably […]
