Atrial Fibrillation
Thursday, December 20th, 2012
Interdependent relationship between atrial fibrillation and sinus rhythm: at the hypothetical interface of atrial fibrillation, autonomic tone, sinoatrial node and inflammation (analytical review, reconsiderations, speculations and new insights) Jafib: 12/20/12 Abstract. Underlying mechanisms of atrial fibrillation occurrence and its self-extinguishing remain not completely investigated yet. The role of autonomic tone and sinoatrial node in the interplay […]
Atrial Fibrillation
Thursday, December 20th, 2012
FDA: 12-19-2012 The U.S. Food and Drug Administration (FDA) is informing health care professionals and the public that the blood thinner (anticoagulant) Pradaxa (dabigatran etexilate mesylate) should not be used to prevent stroke or blood clots (major thromboembolic events) in patients with mechanical heart valves, also known as mechanical prosthetic heart valves. A clinical trial […]
Atrial Fibrillation
Thursday, December 20th, 2012
AHA: 12/19/12 Background—Atrial fibrillation (AF) is a common arrhythmia. Several studies have shown association of genetic variants with AF, and that familial AF increases the risk of AF. We have previously shown a substantial heritability of AF in a twin study. The objective of this study was to determine whether having a co-twin with AF […]
Atrial Fibrillation
Thursday, December 20th, 2012
The Importance of Detecting Dormant Thoracic Vein Conduction AHA: 10/24/12 Background—Pulmonary vein reconnection after electrical isolation is commonly observed in the context of atrial fibrillation ablation and is associated with recurrent atrial tachyarrhythmias. Adenosine test was been performed to identify acute dormant conduction immediately after pulmonary vein isolation at index procedure. However, the utility of […]
Atrial Fibrillation
Thursday, December 20th, 2012
AHA: October 1, 2012 Clinical and Computational Studies of Repolarization Restitution and Activation Latency Background—Mechanisms of atrial fibrillation (AF) initiation are incompletely understood. We hypothesized that rate-dependent changes (restitution) in action potential duration (APD) and activation latency are central targets for clinical interventions that induce AF. We tested this hypothesis using clinical experiments and computer […]
Clinical Trials
Thursday, December 20th, 2012
JAMA: 12/19/12 On November 30, 2010, the regulatory agency for medications in Europe, the European Medicines Agency (EMA), announced a policy on access to “any document originated, received or held by the Agency.”1 The policy made a wide range of regulatory documents potentially accessible to anyone who asks for them, including clinical study reports.2Documents are released […]
Clinical Trials
Thursday, December 20th, 2012
The National Academies Press: 12/19/12 Digital technologies and networks are now part of everyday work in the sciences, and have enhanced access to and use of scientific data, information, and literature significantly. They offer the promise of accelerating the discovery and communication of knowledge, both within the scientific community and in the broader society, as scientific […]
Clinical Trials
Thursday, December 20th, 2012
AHA: 12/18/12 Background and Purpose—Two phase 2 studies of alteplase in acute ischemic stroke 3 to 6 hours after onset, Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET; a randomized, controlled, double-blinded trial), and Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study (DEFUSE; open-label, treatment only) using MR imaging-based outcomes have been conducted. We have […]
Clinical Trials
Thursday, December 20th, 2012
AHA: 12/13/12 Background and Purpose—In a substudy of the International Carotid Stenting Study (ICSS), more patients had new ischemic brain lesions on diffusion-weighted magnetic resonance imaging (MRI) after stenting (CAS) than after endarterectomy (CEA). In the present analysis, we compared characteristics of diffusion-weighted MRI lesions. Methods—Number, individual and total volumes, and location of new diffusion-weighted […]
Clinical Trials
Thursday, December 20th, 2012
SAGE: 12/1/12 Background The clinical trials community has a never-ending search for dependable and reliable ways to improve clinical research. This exploration has led to considerable interest in adaptive clinical trial designs, which provide the flexibility to adjust trial characteristics on the basis of data reviewed at interim stages. Statisticians and clinical investigators have proposed or […]
