News
Friday, March 22nd, 2013
STROKEAHA: March 14, 2013 Background and Purpose—Few prospective studies have examined the impact of both green tea and coffee consumption on strokes. We investigated the association of the combination of those consumption with stroke incidence in a general population. Methods—We studied 82 369 Japanese (aged 45–74 years; without cardiovascular disease [CVD] or cancer in 1995 and […]
Atrial Fibrillation
Friday, March 22nd, 2013
Cardiology News: March 18, 2013 Long-term users of warfarin had difficulty recognizing the clinical severity and urgency of anticoagulation-related situations such as stroke symptoms and medication mismanagement, the results of a survey indicated. “Factual knowledge of the pharmacology of warfarin does not guarantee safe use of warfarin. Enhancing patient education regarding drug-related emergencies will likely […]
Atrial Fibrillation
Friday, March 22nd, 2013
MedPage Today: March 15, 2013 SAN FRANCISCO — Atrial fibrillation feels worse for women, although men are more likely to die from the arrhythmia, a subanalysis of the ORBIT AF registry showed. Women were more symptomatic with a poorer quality of life and greater functional limitations despite similar oral anticoagulation rates and less advanced Afib than […]
Atrial Fibrillation
Friday, March 22nd, 2013
Minerva Medica: March 1, 2013 Department of Cardiology, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia Stroke attributed to atrial fibrillation (AF) confers significant morbidity and mortality. In the past, warfarin has been the only successful stroke prevention agent available. However, it is often underutilized due to its well-known limitations, leaving many patients without adequate […]
Atrial Fibrillation
Friday, March 22nd, 2013
American Heart Journal: February 22, 2013 Background All patients with atrial fibrillation (AF) require optimization of their ventricular rate. Factors leading to use of additional rhythm control in clinical practice have not been thoroughly defined. Methods The ORBIT-AF registry enrolled patients with AF from a broad range of practice settings and collected data on rate versus […]
Clinical Trials
Friday, March 22nd, 2013
International Journal of Stroke: March 19, 2013 Background Aphasia affects up to a third of the stroke population and is associated with poor social participation and quality of life. Yet people with aphasia may be excluded from some types of stroke research due to challenges in informing, consenting, and conducting follow-up in this population. Aims […]
Clinical Trials
Friday, March 22nd, 2013
PLOS Medicine: Background At the time of approval of a new medicine, there are few long-term data on the medicine’s benefit–risk balance. Clinical trials are designed to demonstrate efficacy, but have major limitations with regard to safety in terms of patient exposure and length of follow-up. This study of the number of patients who had […]
Clinical Trials
Friday, March 22nd, 2013
JAMA: March 18, 2013 It may appear that the clinical research enterprise is functioning well, even thriving. Nearly 30 000 trials globally are recruiting patients, and results from 75 trials are published daily in biomedical journals.However, there is a crisis, with an attendant opportunity, that requires change. A wall surrounds much of these clinical research data, sequestering knowledge, impeding the […]
Clinical Trials
Friday, March 22nd, 2013
International Journal of Stroke: March 15, 2013 Background and purpose We aimed to assess the safety, feasibility, and effects on glucose metabolism of treatment with metformin in patients with TIA or minor ischemic stroke and impaired glucose tolerance. Methods We performed a multicenter, randomized, controlled, open-label phase II trial with blinded outcome assessment. Patients with […]
Clinical Trials
Friday, March 22nd, 2013
American Heart Journal: March 13, 2013 Numerous challenges—financial, regulatory, and cultural—are hindering US participation and performance in multinational clinical trials. Consequently, it is increasingly unclear how the results of these trials should be applied to American patients, practice patterns, and systems of care. Both incremental and transformative changes are needed to revitalize US participation as […]
