Atrial Fibrillation
Thursday, March 14th, 2013
Wiley: March 12, 2013 Background Atrial fibrillation is associated with greater baseline neurological impairment and worse outcomes following ischemic stroke. Previous studies suggest that greater volumes of more severe baseline hypoperfusion in patients with history of atrial fibrillation may explain this association. We further investigated this association by comparing patients with and without atrial fibrillation […]
Atrial Fibrillation
Thursday, March 14th, 2013
JACC: March 10, 2013 Background A large proportion of atrial fibrillation (AF) patients do not receive guideline-recommended thromboprophylaxis, leaving them at risk for stroke and death. Using data from the 1st cohort of the prospective GARFIELD Registry, we characterized factors associated with non-use of vitamin K antagonists (VKA) for stroke prevention in AF. Read more
Atrial Fibrillation
Thursday, March 14th, 2013
CIRCEP: March 9, 2013 Background—Iatrogenic myocardial injury by radiofrequency catheter ablation (RFCA) releases pro-inflammatory substances from damaged myocardium, and these may contribute to endothelial dysfunction in systemic vascular structure. The aim of this study is to evaluate effect of non-ischemic myocardial damage on coronary microvascular function in patients undergoing atrial fibrillation (AF) ablation. Methods and Results—We […]
Clinical Trials
Thursday, March 14th, 2013
STROKEAHA: March 12, 2013 Background and Purpose—Most randomized controlled trials of venous thromboembolism prophylaxis have focused on reduction of deep vein thrombosis, predominantly asymptomatic deep vein thrombosis, detected on imaging. We aimed to estimate the effects of graduated compression stockings on venous thromboembolism events, survival, and functional status at 6 months after stroke. Methods—The CLOTS Trials […]
Clinical Trials
Thursday, March 14th, 2013
Wiley: March 12, 2013 Objective. Chronic stroke patients with severe hand weakness, respond poorly to rehabilitation efforts. Here, we evaluated efficacy of daily brain-machine-interface training to increase the hypothesized beneficial effects of physiotherapy alone in patients with severe paresis in a double blind sham-controlled design proof of concept study. Methods. 32 chronic stroke patients with […]
Clinical Trials
Thursday, March 14th, 2013
STROKEAHA: March 7, 2013 Background and Purpose—Little is known about the effects of community-based walking programs in persons with chronic stroke. The purpose of this study was to determine the effects of aerobic (walking) training on functional status and health-related quality of life in stroke survivors. Methods—A single-blind randomized controlled trial was conducted. The intervention group […]
Clinical Trials
Thursday, March 14th, 2013
JACC: March 1, 2013 Objectives To compare catheter ablation with rate-control for persistent atrial fibrillation (AF) in heart failure (HF). Background The optimal therapy for AF in HF is unclear. Drug-based rhythm-control has not proved clinically beneficial. Catheter ablation improves cardiac function in patients with HF, but impact on physiological performance has not been formally evaluated in […]
Clinical Trials
Thursday, March 14th, 2013
NEJM: February 6, 2013 BACKGROUND In patients with ischemic stroke, endovascular treatment results in a higher rate of recanalization of the affected cerebral artery than systemic intravenous thrombolytic therapy. However, comparison of the clinical efficacy of the two approaches is needed. METHODS We randomly assigned 362 patients with acute ischemic stroke, within 4.5 hours after […]
Therapies
Thursday, March 14th, 2013
Neurology: March 13, 2013 Objective: Prominent fibrinogen cleavage by recombinant tissue plasminogen activator and formation of fibrinogen degradation products with anticoagulant properties was proposed to amplify the risk of thrombolysis-related bleeding complications, but supportive evidence mainly derived from studies on myocardial infarction. Methods: This study included 547 consecutive stroke patients treated with recombinant tissue plasminogen activator, who underwent […]
Therapies
Thursday, March 14th, 2013
Wiley: March 12, 2013 Background Race-ethnic differences may influence postthrombolysis outcomes in acute ischemic stroke patients. Guidelines for thrombolytic therapy to treat Asian stroke patients are based mostly on extrapolated western data. Aims We undertook to examine outcomes among Asians by comparing a propensity-matched cohort of thrombolyzed patients from a tertiary center in Singapore with […]
