Atrial Fibrillation in the 21st Century: A Current Understanding of Risk Factors and Primary Prevention Strategies

Mayo Clinic Proceedings: April 1, 2013 Abstract Atrial fibrillation (AF) is the most common arrhythmia worldwide, and it has a significant effect on morbidity and mortality. It is a significant risk factor for stroke and peripheral embolization, and it has an effect on cardiac function. Despite widespread interest and extensive research on this topic, our understanding […]

Incidence of atrial fibrillation detected by implantable loop recorders in unexplained stroke

Neurology: March 27, 2013 Objectives: The usefulness of the implantable loop recorder (ILR) with improved atrial fibrillation (AF) detection capability (Reveal XT) and the factors associated with AF in the setting of unexplained stroke were investigated. Methods: A cohort study is reported of 51 patients in whom ILRs were implanted for the investigation of ischemic stroke for which […]

Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials

BMJ: April 4, 2013 Objective To determine the effects of longer term modest salt reduction on blood pressure, hormones, and lipids. Design Systematic review and meta-analysis. Data sources Medline, Embase, Cochrane Hypertension Group Specialised Register, Cochrane Central Register of Controlled Trials, and reference list of relevant articles. Inclusion criteria Randomised trials with a modest reduction in salt intake and […]

Many U.S. Blacks Eager to Take Part in Medical Research

Health Day: April 12, 2013 THURSDAY, April 4 (HealthDay News) — Black Americans are more likely than other racial/ethnic groups to be interested in participating in medical research, including when it involves providing blood or genetic samples, a new study finds. Now the challenge is to better match that interest with greater inclusion in clinical trials, […]

Favorable Vascular Profile is an Independent Predictor of Outcome

STROKEAHA: April 2, 2013 Background and Purpose—We hypothesized that a favorable vascular profile (FVP) defined as anatomic intactness of the Circle of Willis combined with a stable cerebral perfusion pressure (mean arterial blood pressure>65 mm Hg) is a prerequisite for collateral recruitment and maintenance and may improve outcome. We performed post hoc analyses of a subset […]

Stroke After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction

CIRCINTERVENTIONS: April 2, 2013 Background—Stroke is a rare but potentially devastating complication of acute myocardial infarction. Little is known about stroke timing, characteristics, and clinical outcomes in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention (PCI). Methods and Results—We studied 5372 patients enrolled in the Assessment of Pexelizumab in Acute Myocardial Infarction […]

Malignant Emboli on Transcranial Doppler During Carotid Stenting Predict Postprocedure Diffusion-Weighted Imaging Lesions

​STROKEAHA: March 26, 2013 Background and Purpose—Carotid angioplasty and stenting (CAS) has a higher incidence of periprocedural stroke compared with endarterectomy. Identifying CAS steps with the highest likelihood of embolization may have important implications. We evaluated CAS safety by correlating the findings of procedural transcranial Doppler with postprocedure diffusion-weighted imaging (DWI) lesions. Methods—In this prospective study, […]

Thrombolysis Despite Recent Stroke

STROKEAHA: April 2, 2013 Background and Purpose—Thrombolysis in ischemic stroke is contraindicated in patients who have had a stroke within 3 months. However, it is unclear whether thrombolytic therapy is associated with adverse outcomes in this population. We report the characteristics and outcomes of patients treated with systemic recombinant tissue-type plasminogen activator in the context of […]

Management of Patients With Atrial Fibrillation

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AHA Circulation: April 1, 2013 Introduction This document is a compilation of the current American Col- lege of Cardiology Foundation/American Heart Association (ACCF/AHA) practice guideline recommendations for atrial fibrillation (AF) from the “ACC/AHA/esC 2006 Guidelines for the Management of Patients With Atrial Fibrillation),”⁎ the “2011 ACCF/AHA/Hrs Focused Update on the Management of Patients With Atrial Fibrillation […]

ASTRAL Score Predicts 5-Year Dependence and Mortality in Acute Ischemic Stroke

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​STROKEAHA: April 4, 2013 Background and Purpose—The ASTRAL score was externally validated showing remarkable consistency on 3-month outcome prognosis in patients with acute ischemic stroke. The present study aimed to evaluate ASTRAL score’s prognostic accuracy to predict 5-year outcome. Methods—All consecutive patients with acute ischemic stroke registered in the Athens Stroke Registry between January 1, 1998, […]

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