Non-pharmacological strategies for the treatment of acute ischaemic stroke

The Lancet Neurology: June 1, 2013 Early recanalisation and an increase in collateral blood supply are predictors of favourable outcome in acute ischaemic stroke. Since individual responses to intravenous treatment with alteplase are heterogeneous, additional intra-arterial thrombolytic and mechanical endovascular treatment is increasingly given. Despite encouraging findings from single-centre studies, data from randomised clinical trials […]

Streamlining of prehospital stroke management: the golden hour

The Lancet Neurology: June 1, 2013 Thrombolysis with alteplase administered within a narrow therapeutic window provides an effective therapy for acute ischaemic stroke. However, mainly because of prehospital delay, patients often arrive too late for treatment, and no more than 1—8% of patients with stroke obtain this treatment.  Read more

Clinical Outcomes Strongly Associated With the Degree of Reperfusion Achieved in Target Mismatch Patients

STROKEAHA: May 23, 2013 Background and Purpose—To investigate relationships between the degree of early reperfusion achieved on perfusion-weighted imaging and clinical outcomes in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution studies. We hypothesized that there would be a strong correlation between the degree of reperfusion achieved and clinical outcomes in target mismatch (TMM) […]

Functional cortical reorganization after low-frequency repetitive transcranial magnetic stimulation plus intensive occupational therapy for upper limb hemiparesis: evaluation by functional magnetic resonance imaging in poststroke patients

International Journal of Stroke: May 22, 2013 Background Low-frequency repetitive transcranial magnetic stimulation of the nonlesional hemisphere combined with occupational therapy significantly improves motor function of the affected upper limb in poststroke hemiparetic patients, but the recovery mechanism remains unclear. Aims To investigate the recovery mechanism using functional magnetic resonance imaging.  Read more

Endovascular Treatment of Intracranial Aneurysms in Elderly Patients

STROKEAHA: May 16, 2013 Background and Purpose—Use of endovascular coiling for treatment of ruptured and unruptured intracranial aneurysms (IAs) in the elderly is increasing. We performed a meta-analysis of the literature examining clinical and angiographic outcomes for treatment of IAs in the elderly. Methods—We performed a comprehensive review of the literature from 1995 to 2012, reporting […]

AHA/ASA Policy Statement Forecasting the Future of Stroke in the United States

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StrokeAHA: May 22, 2013 Background and Purpose—Stroke is a leading cause of disability, cognitive impairment, and death in the United States and accounts for 1.7% of national health expenditures. Because the population is aging and the risk of stroke more than doubles for each successive decade after the age of 55 years, these costs are anticipated […]

Racial and Ethnic Differences in Outcomes in Older Patients With Acute Ischemic Stroke

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CIRCOUTCOMES: May 16, 2013 Background—Little is known as to whether long-term outcomes of acute ischemic stroke (AIS) vary by race/ethnicity. Using the American Heart Association Get With The Guidelines–Stroke registry linked with Medicare claims data set, we examined whether 30-day and 1-year outcomes differed by race/ethnicity among older patients with AIS. Methods and Results—We analyzed 200 […]

Baseline Cognitive Function, Recurrent Stroke, and Risk of Dementia in Patients With Stroke

STROKEAHA: May 16, 2013 Background and Purpose—To determine the interrelationships between baseline Mini-Mental State Examination (MMSE) score and risk of overall dementia, post-recurrent stroke dementia, and dementia without recurrent stroke among patients with a history of stroke. Methods—Prospective cohort study among participants enrolled in the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) for whom baseline MMSE […]

Framingham Stroke Risk Score and Cognitive Impairment for Predicting First-Time Stroke in the Oldest Old

STROKEAHA: May 16, 2013 Background and Purpose—Predictive value of the conventional risk factors for stroke attenuates with age. Cognitive impairment has been implicated as a potential predictor for stroke in older subjects. Our aim was to compare the Framingham stroke risk score with cognitive functioning for predicting first-time stroke in a cohort of the oldest old […]

Renal Impairment and Ischemic Stroke Risk Assessment in Patients With Atrial Fibrillation

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J Am Coll Cardiology: May 21, 2013 Objectives  This study sought to determine the risk of ischemic stroke (IS)/thromboembolism (TE) associated with renal impairment and its incremental predictive value over established risk stratification scores (congestive heart failure, hypertension, age ≥75 years, diabetes, previous stroke [CHADS2] and congestive heart failure, hypertension, age ≥75 years, diabetes, previous stroke, […]

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