Clinical Trials
Tuesday, June 18th, 2013
CIRCULATIONAHA: June 14, 2013 Background—During follow up of between 1 and 3 years in the RE-LY trial, two doses of dabigatran etexilate were shown to be effective and safe for prevention of stroke or systemic embolism in patients with atrial fibrillation (AF). There is a need for longer term follow up of patients on dabigatran […]
Clinical Trials
Tuesday, June 18th, 2013
STROKEAHA: June 13, 2013 Background and Purpose—High plasma total homocysteine (tHcy) has been associated with cognitive impairment but lowering tHcy with B-vitamins has produced equivocal results. We aimed to determine whether B-vitamin supplementation would reduce tHcy and the incidence of new cognitive impairment among individuals with stroke or transient ischemic attack ≥6 months previously. Methods—A […]
Clinical Trials
Tuesday, June 18th, 2013
Statistics in Medicine: June 12, 2013 A post-hoc individual patient matching procedure was recently proposed within the context of parallel group randomized clinical trials (RCTs) as a method for estimating treatment effect. In this paper, we consider a post-hoc individual patient matching problem within a parallel group RCT as a multi-objective decision-making problem focussing on […]
Clinical Trials
Tuesday, June 18th, 2013
Research America: June 12, 2013 More than two-thirds (72%) of Americans say it’s likely they would participate in a clinical trial if recommended by their doctor, but only 22% say a doctor or other health care professional has ever talked to them about medical research, according to a new national public opinion poll commissioned by […]
Clinical Trials
Tuesday, June 18th, 2013
CIRCOUTCOMES: June 11, 2013 Background—To evaluate the previously reported excess of thromboembolic events during the 30 days after the end of study (EOS) visit when participants transitioned from blinded therapy to open-label vitamin K antagonist. Methods and Results—At the EOS visit, open-label vitamin K antagonist was recommended, and the international normalized ratio (INR) was not to […]
Therapies
Tuesday, June 18th, 2013
J NeuroIntervent Surgery: June 15, 2013 Background and purpose The optimal management of stroke patients who fail treatment with intravenous recombinant tissue plasminogen activator (rt-PA) remains unknown. A study was undertaken to establish whether treatment with a standard intravenous t-PA dose (0.9 mg/kg) followed by multimodal endovascular therapy would have a similar safety profile to reduced dose […]
Therapies
Tuesday, June 18th, 2013
PhRMA: June 14, 2013 Biopharmaceutical research companies are developing 215 medicines for two of the leading causes of death in Ameri- cans—heart disease and stroke. Medi- cines have helped cut deaths from these diseases by 30 percent between 2001 and 2011, and in 2008 stroke dropped to the fourth leading cause of death after being […]
Therapies
Tuesday, June 18th, 2013
STROKEAHA: June 11, 2013 Background and Purpose—Diffusion-weighted imaging (DWI) lesion volume is associated with poor outcome after thrombolysis, and it is unclear whether endovascular therapies are beneficial for large DWI lesion. Our aim was to assess the impact of pretreatment DWI lesion volume on outcomes after endovascular therapy, with a special emphasis on patients with complete […]
Therapies
Tuesday, June 18th, 2013
STROKEAHA: June 11, 2013 Background and Purpose—The purpose of this study was to analyze the 30-day outcome after introduction of a rapid carotid endarterectomy (CEA) program. Reasons for delay in CEA and the incidence of early recurrence neurological symptoms were recorded. Methods—This is a prospective population-based study of delays to CEA and 30-day outcome in patients […]
Guidelines, Therapies
Tuesday, June 18th, 2013
Neurology June 11, 2013 Objective: Specific guidelines for management of cerebrovascular risk in women are currently lacking. This study aims to provide a consensus expert opinion to help make clinical decisions in women with carotid stenosis. Methods: Proposals for the use of carotid endarterectomy (CEA), carotid stenting (CAS), and medical therapy for stroke prevention in women with carotid […]
