Atrial Fibrillation
Sunday, June 16th, 2013
PLOS one – 5/29/13 Background Gender-based clinical differences are increasingly being identified as having significant influence on the outcomes of patients with cardiovascular disease (CVD), including atrial fibrillation (AF). Objective To perform detailed clinical phenotyping on a cohort of hospitalised patients with chronic forms of AF to understand if gender-based differences exist in the clinical […]
Clinical Trials
Sunday, June 16th, 2013
AHA – June 7, 2013 Background—The aim of this prospective randomized study was to assess if an early re-ablation was superior to AAD therapy in patients with previous failed PVI. Methods and Results—Patients with paroxysmal AF eligible for AAD therapy or re-ablation after a previous failed initial PVI procedure were eligible for this study and […]
Clinical Trials
Sunday, June 16th, 2013
Effects on Ischemic and Hemorrhagic Strokes and Bleeding in Asians and Non-Asians With Atrial Fibrillation Background and Purpose—Intracranial hemorrhage rates are higher in Asians than non-Asians, especially in patients receiving warfarin. This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from […]
Clinical Trials
Sunday, June 16th, 2013
Nature – June 05, 2013 It is time for a far-reaching and comprehensive review of the way US government-backed clinical research is funded and approved. Ethical reviews of much of this work are currently inadequate and problems come to light too late. In the most recent example, the US Department of Health and Human Services […]
Clinical Trials
Sunday, June 16th, 2013
The Cochrane Library – JUN 4, 2013 Current guidelines recommend oral anticoagulation therapy for patients with atrial fibrillation who are at moderate-to-high risk of stroke, however anticoagulation control (time in therapeutic range (TTR)) is dependent on many factors. Educational and behavioural interventions may impact on patients’ ability to maintain their International Normalised Ratio (INR) control. […]
Clinical Trials
Sunday, June 16th, 2013
AHA – June 4, 2013 Background and Purpose—The goal of this randomized, open-label phase II study was to investigate the effect of concomitant low-frequency head-motion therapy and intraventricular fibrinolysis in patients after surgical or endovascular treatment for aneurysmal subarachnoid hemorrhage. Methods—Sixty patients experiencing subarachnoid hemorrhage were randomized into treatment with intraventricular application of recombinant tissue-type […]
Therapies
Sunday, June 16th, 2013
Background: Controversy surrounds the safety of intravenous (IV) tissue plasminogen activator (tPA) in ischemic stroke patients treated with warfarin. The European tPA license precludes its use in anticoagulated patients altogether. American guidelines accept IV tPA use with an international normalized ratio (INR) ≤1.7. The influence of warfarin on symptomatic intracerebral hemorrhage (SICH), arterial recanalization and […]
Therapies
Sunday, June 16th, 2013
The Lancet Neurology: May 31, 2013. Systemic thrombolysis with alteplase is the only approved medical treatment for patients with acute ischaemic stroke. Thrombectomy is also increasingly used to treat proximal occlusions of the cerebral arteries, but has not shown superiority over systemic thrombolysis with alteplase. Many patients with acute ischaemic stroke are pretreated with antiplatelet or […]
Therapies
Sunday, June 16th, 2013
AHA – May 30, 2013 Background and Purpose—Wake-up ischemic stroke (WUIS) patients are not thrombolysed even if they meet other criteria for treatment. We hypothesized that patients with WUIS showing no or early ischemic changes on brain imaging will have thrombolysis outcomes comparable with those with known time of symptom onset. Methods—Consecutive sampling of a […]
Therapies
Sunday, June 16th, 2013
AHA – May 30, 2013 Background and Purpose—Flow diversion has emerged as an important tool for the management of intracranial aneurysms. The purpose of this study was to compare flow diversion and traditional embolization strategies in terms of safety, efficacy, and clinical outcomes in patients with unruptured, large saccular aneurysms (≥10 mm). Methods—Forty patients treated […]
