Clinical Trials
Friday, June 7th, 2013
J NeuroIntervent Surgery: May 28, 2013 Background and purpose The use of stentrievers (ST) is rapidly growing due to several potential benefits over other available treatments. ST potentially restore flow before clot retrieval and reduce procedural time. We aimed to study the impact of these potential benefits. Methods Patients with acute stroke treated with endovascular procedures in […]
Clinical Trials
Friday, June 7th, 2013
Medical Xpress: May 27, 2013 Updated interim data from the PISCES trial, which has seen the brains of ischaemic stroke patients injected with neural stem cells to test the safety and tolerability of the treatment, was presented to the 22nd European Stroke Conference in London today. Professor Keith Muir of the University of Glasgow, who is […]
Clinical Trials
Friday, June 7th, 2013
Stroke. May 16, 2013 The Solitaire With the Intention for Thrombectomy (SWIFT) trial1 and the TREVO II trial,2published online in Lancet in August 2012, are important trials in the history of endovascular therapy for acute ischemic stroke for several reasons. First, both randomized trials compared a new technology, 2 versions of a stent-retriever, with a previously Food and […]
Therapies
Friday, June 7th, 2013
Stroke: June 1, 2013 The only treatment shown to improve outcome in acute ischemic stroke is tissue-type plasminogen activator administered within 3 hours (and perhaps longer) after stroke onset.1–3 Definitive data to support a role for acute endovascular stroke therapy, however, are lacking. Despite this lack of data, endovascular therapy is being used much more widely […]
Therapies
Friday, June 7th, 2013
Stroke. June 1, 2013 Stroke-related mortality in the United States fell by nearly 35% between 1999 and 2008. Arguably, the reduction was largely the result of reduced stroke incidence, a reflection of improved prevention.1 Consistent with this observation, the failures of several recent secondary stroke prevention trials were, in part, attributable to lower than historically expected […]
Therapies
Friday, June 7th, 2013
Annals of Neurology: May 30, 2013 ABSTRACT Approximately 700,000 people in the United States have an ischemic stroke annually. Substantial research has tested therapies for the very early treatment of ischemic stroke but, to date, only intravenous thrombolysis and intra-arterial measures to restore perfusion have shown success. Despite a 15-year effort to increase the use […]
Therapies
Friday, June 7th, 2013
STROKEAHA. May 28, 2013 Background and Purpose—An earlier study demonstrated significantly improved access, treatment, and outcomes after the implementation of a progressive, comprehensive stroke program at a tertiary care community hospital, Saint Luke’s Neuroscience Institute (SLNI). This study evaluated the costs associated with implementing such a program. Methods—Retrospective analysis of total hospital costs and payments for […]
Guidelines, Therapies
Friday, June 7th, 2013
Neurology May 28, 2013 Objective: To assess evidence regarding periprocedural management of antithrombotic drugs in patients with ischemic cerebrovascular disease. The complete guideline on which this summary is based is available as an online data supplement to this article. Methods: Systematic literature review with practice recommendations. Results and recommendations: Clinicians managing antithrombotic medications periprocedurally must weigh bleeding risks from […]
Guidelines
Friday, June 7th, 2013
JAMA May 27, 2013 Two philosophical approaches to the implementation of optimal health care are emerging—the use of evidence-based guidelines and the application of personalized (or “precision”) medicine. Even though both approaches have important merits, they both also can present conflicting priorities that must be reconciled before they can be best leveraged. Evidence-based guidelines are generated based on […]
News
Friday, June 7th, 2013
Stroke June 1, 2013 There have been advances in understanding the molecular underpinnings of risk and response to stroke hailing from genetic research. Traditional linkage studies were limited to identifying genetic mutations, representing small fractions of human disease burden. Yet with large-scale genotyping, RNA expression studies and microRNA analyses, modern genetic research has opened the […]
