Magnetic resonance imaging before ablation for atrial fibrosis helps predict success of treatment

Medicalxpress: September 1, 2013 In patients with atrial fibrillation, delayed enhancement magnetic resonance imaging (DE-MRI) performed before ablative treatment can stage the degree of damaged heart tissue (atrial fibrosis) and help predict whether treatment will be successful or not, according to results of Delayed Enhancement – MRI determinant of successful Catheter Ablation of Atrial Fibrillation (DECAAF) […]

Mass screening identifies untreated AF in 5% of 75-76 year olds

Medicalxpress: September 1, 2013 Stroke is the second cause of death worldwide. Atrial fibrillation is the most common clinically relevant cardiac arrhythmia in Europe, affecting approximately 1.5-2% of the general population.1 Prevalence is estimated to double in the next 50 years as the population ages. Patients with atrial fibrillation have a five-fold increased risk of ischaemic stroke even […]

Neuropsychological Effects of MRI-Detected Brain Lesions after Left Atrial Catheter Ablation for Atrial Fibrillation: Long Term Results of the MACPAF Study

​CIRCEP: August 29, 2013 Background—Magnetic resonance imaging (MRI)-detected brain lesions are common following left atrial catheter ablation (LACA) for symptomatic atrial fibrillation. The clinical relevance of these acute ischemic lesions is not fully understood, but ablation-related cerebral injury could contribute to cognitive dysfunction. Methods and Results—In the prospective “Mesh Ablator versus Cryoballoon Pulmonary Vein Ablation of […]

Good Outcome Rate of 35% in IV-tPA–Treated Patients With Computed Tomography Angiography Confirmed Severe Anterior Circulation Occlusive Stroke

STROKEAHA: September 3, 2013 Background and Purpose—To determine the effect of intravenous tissue plasminogen activator (IV-tPA) on outcomes in patients with severe major anterior circulation ischemic stroke. Methods—Prospectively, 649 patients with acute stroke had admission National Institutes of Health stroke scale (NIHSS) scores, noncontrast computed tomography (CT), CT angiography (CTA), and 6-month outcome assessed using modified […]

Severe Renal Impairment Is Associated With Symptomatic Intracerebral Hemorrhage After Thrombolysis for Ischemic Stroke

STROKEAHA: September 3, 2013 Background and Purpose—Patients with renal impairment (RI) have an increased risk of both thrombotic and hemorrhagic events. We aimed to clarify whether RI increases the risk of intracerebral hemorrhage (ICH) after intravenous thrombolysis with recombinant tissue plasminogen activator. Methods—Patients who received intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 hours of […]

Intraprocedural parenchymal blood volume as a marker of reperfusion status in acute ischemic stroke intervention

J NeuroIntervent Surg: 8/30/13 Parenchymal blood volume (PBV) mapping with flat panel detectors may provide real-time estimates of tissue perfusion during endovascular ischemic stroke procedures. We present two cases of acute middle cerebral artery (MCA) occlusion to demonstrate how PBV may: (1) be used in acute stroke; (2) influence intraprocedural decision-making; and (3) potentially serve as […]

Preventable Deaths from Heart Disease & Stroke

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CDC: September 2013 At least 200,000 deaths from heart disease and stroke each year are preventable.* 6 in 10 More than half of preventable heart disease and stroke deaths happen to people under age 65. 2x Blacks are nearly twice as likely as whites to die from preventable heart disease and stroke. Nearly 1 in […]

Impact of Both Ends of the Hemoglobin Range on Clinical Outcomes in Acute Ischemic Stroke

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STROKEAHA: September 3, 2013 Background and Purpose—Although both ends of the hemoglobin range may negatively influence clinical outcomes in acute ischemic stroke, most studies have examined the linear relationship or focused on the lower end of the range. Furthermore, it is unclear whether hemoglobin concentrations at different time points during hospitalization correlate with clinical outcomes in […]

Cholesterol Level and Stroke A Complex Relationship

JAMA: 9/2/13 Identification of the role that plasma lipid components play in the pathogenesis of ischemic heart disease is one of the major successes of biomedical research in the 20th century. It has led to successful public health and individual-level interventions for lowering cholesterol levels as part of the strategy for prevention of ischemic heart disease. […]

Low Glomerular Filtration Rate, Recurrent Stroke Risk, and Effect of Renin–Angiotensin System Modulation

STROKEAHA: August 29, 2013   Background and Purpose—To investigate the association of low estimated glomerular filtration rate (eGFR) <60 mL/min with recurrent stroke risk and to evaluate whether add-on renin–angiotensin system modulator therapy is associated with lower recurrent stroke risk in patients with low eGFR. Methods—We analyzed the database of a multicenter trial involving 18 666 […]

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