Atrial Fibrillation
Thursday, October 10th, 2013
J Am Coll Cardiol: 10/1/13 Persistent iatrogenic atrial septal defect (iASD) after transseptal puncture for radiofrequency (RF) ablation of atrial fibrillation (AF) using 8-F sheaths has been reported at rates of 0 to 19% at medium-term follow-up, depending on the transseptal puncture technique, the follow-up interval, and whether transthoracic echocardiography (TTE) or transesophageal echocardiography was used for […]
Atrial Fibrillation
Thursday, October 10th, 2013
JACC: October 2013 A Translational Proof-of-Concept Study in Patients With Metabolic Syndrome in Whom Post-Operative Atrial Fibrillation Develops Objectives This study sought to provide bedside evidence of the potential link between cardiac mitochondrial dysfunction and arrhythmia as reported in bench studies. Background Atrial fibrillation (AF) is a frequent complication of cardiac surgery. Underlying mechanisms of post-operative atrial fibrillation (POAF) remain largely unknown. […]
Atrial Fibrillation
Thursday, October 10th, 2013
PLOS: 10/8/13 Access to unpublished clinical study reports (CSRs) is currently being discussed as a means to allow unbiased evaluation of clinical research. The Institute for Quality and Efficiency in Health Care (IQWiG) routinely requests CSRs from manufacturers for its drug assessments. Our objective was to determine the information gain from CSRs compared to publicly available […]
Clinical Trials
Thursday, October 10th, 2013
CIRCEP: October 4, 2013 Background—In patients treated for paroxysmal atrial fibrillation (AF), the pulmonary vein (PV) reconnection rate is substantial and may be related to the lack of transmurality achievement while performing PV isolation (PVI). It has been experimentally demonstrated that positive unipolar atrial electrogram completion, when applying radiofrequency (RF) energy, was associated with transmural lesions. […]
Clinical Trials
Thursday, October 10th, 2013
J Am Coll Cardiol: 10/1/13 Objectives This study was designed to assess whether the reinforcement of the antioxidant system, through n-3 fatty acids plus antioxidant vitamin supplementation, could reduce the incidence of post-operative atrial fibrillation. Background Therapy to prevent post-operative atrial fibrillation remains suboptimal. Although oxidative stress plays a key role in the pathogenesis of this arrhythmia, […]
Clinical Trials
Thursday, October 10th, 2013
J Am Coll Cardiol: 10/1/13 Objectives This study was designed to assess whether the reinforcement of the antioxidant system, through n-3 fatty acids plus antioxidant vitamin supplementation, could reduce the incidence of post-operative atrial fibrillation. Background Therapy to prevent post-operative atrial fibrillation remains suboptimal. Although oxidative stress plays a key role in the pathogenesis of this […]
Clinical Trials
Thursday, October 10th, 2013
CIRCULATIONAHA: September 30, 2013 Background—The aim of this study was to compare the management and prognosis of major bleeding in patients treated with dabigatran or warfarin. Methods and Results—Two independent investigators reviewed bleeding reports from 1,034 individuals with 1,121 major bleeds enrolled in 5 phase III trials comparing dabigatran with warfarin in 27,419 patients treated for […]
Therapies
Thursday, October 10th, 2013
Wiley: 10/9/13 The field of neurorehabilitation aims to translate neuroscience research toward the goal of maximizing functional recovery after neurological injury. A growing body of research indicates that the fundamental principles of neurological rehabilitation are applicable to a broad range of congenital, degenerative, and acquired neurological disorders. In this perspective, we will focus on motor recovery […]
Therapies
Thursday, October 10th, 2013
J NeuroIntervent Surg: 10.9.13 Background and purpose The relationship between dense packing and incidence of angiographic recurrence after endovascular treatment of intracranial aneurysms has been shown but remains controversial. We retrospectively analyzed intracranial aneurysms treated with detachable coils to determine the relation between aneurysm volume, packing, and recurrence. Methods We reviewed 221 aneurysms in 199 patients who […]
Guidelines, Therapies
Thursday, October 10th, 2013
Implementation Science: October 1, 2013 Background Multiple guidelines are often available to inform practice in complex interventions. Guidance implementation may be facilitated if it is tailored to particular clinical issues and contexts. It should also aim to specify all elements of interventions that may mediate and modify effectiveness, including both their content and delivery. We conducted […]
