Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation
Atrial Fibrillation
Sunday, April 8th, 2012
Biomedcentral.com: April 4, 2012.
Background: Atrial fibrillation (AF) is the most common arrhythmia. The potassium current IKs is essential for cardiac repolarization. Gain-of-function mutations in KV7.1, the pore-forming alpha-subunit of the IKs channel, have been associated with AF. We hypothesized that early-onset lone AF is associated with mutations in the IKs channel regulatory subunit KCNE1.
Methods: In 209 unrelated early-onset lone AF patients (< 40 years) the entire coding sequence of KCNE1 was bidirectionally sequenced. We analyzed the identified KCNE1 mutants electrophysiologically in heterologous expression systems. Read more
