Relevance of Electrical Remodeling in Human Atrial Fibrillation: Results of the ASSERT Mechanisms of Atrial Fibrillation Study

Clinical Trials Friday, June 8th, 2012

Circep.ahajournals.org:  June 5, 2012.

Background—In animal models of atrial fibrillation (AF), changes in atrial electrophysiologic (EP) properties are associated with the development of AF. Their relevance to human AF is unclear.

Methods and Results—The ASSERT trial enrolled 2580 patients receiving a dual-chamber pacemaker, who were over the age of 65 years and had a history of hypertension, but no history of AF. Serial non-invasive EP testing was performed over 2 years, in a sub-group of 485 patients. There were no differences in clinical characteristics between patients with and without device-detected atrial tachyarrhythmias (AT) during the first year. Read More

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