Citicoline did not improve recovery at 90 days after moderate-to-severe acute ischemic stroke

Annals.org: September 18, 2012
Patients: 2298 adults ≥ 18 years of age (mean age 73 y, 50% women) who had acute ischemic stroke referable to the middle cerebral artery territory with compatible neuroimaging; symptom onset within 24 hours; score ≥ 8 on the National Institutes of Health Stroke Scale (NIHSS), of which ≥ 2 points were from sections 5 and 6; prestroke modified Rankin score of 0 or 1; ≤ 12 hours between hospital admission and randomization; and < 1 hour between randomization and first dose of study drug.

Intervention: Citicoline, 1000 mg every 12 hours (n = 1148), or placebo (n = 1150), for 6 weeks. Citicoline was administered intravenously for the first 3 days and orally from day 4 through week 6. Read more