Blood–brain barrier disruption is associated with increased mortality after endovascular therapy

Therapies Monday, February 4th, 2013

Neurology: January 30, 2013

Objective: To evaluate the incidence, baseline characteristics, and clinical prognosis of blood–brain barrier (BBB) disruption after endovascular therapy in acute ischemic stroke patients.

Methods: A total of 220 patients treated with endovascular therapy between April 2007 and October 2011 were identified from a prospective, clinical, thrombolysis registry. All patients underwent a nonenhanced CT scan immediately after treatment. CT scan or MRI was systematically realized at 24 hours to assess intracranial hemorrhage complications. BBB disruption was defined as a hyperdense lesion on the posttreatment CT scan. Read more

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