Pulmonary Antrum Radial-Linear Ablation for Paroxysmal Atrial Fibrillation: Interim Analysis of a Multicenter Trial
Clinical Trials Wednesday, March 6th, 2013CIRCEP: February 22, 2013
Background—Substrate abnormality in pulmonary vein (PV) antrum plays a critical role in mechanism of atrial fibrillation (AF). The present study compares the strategy of PV antrum radial-linear (PAR) ablation to encircling PV isolation for paroxysmal AF.
Methods and Results—A total of 86 patients with paroxysmal AF were randomly assigned to PAR ablation group or PV isolation group. The average procedure time was 161±21 min in PAR ablation group and 199±39 min in PV isolation group (P<0.01). The average fluoroscopy time was 25±5 min in PAR ablation group and 32±9 min in PV isolation group (P<0.001). At 14 (15-12) months of follow-up after single procedure, 31 of 42 (74%) patients in PAR ablation group and 22 of 44 patients (50%) in PV isolation group had no recurrence of AF off antiarrhythmic drug (AAD) (P=0.0249); and 36 of 42 patients (86%) in PAR ablation group and 26 of 44 patients (59%) in PV isolation group had no recurrence of AF with AAD (P=0.006). In addition, PAR ablation resulted in greater reduction of LA diameter than encircling PV isolation. Multivariable Cox regression analysis showed that only ablation strategy was independently associated with AF recurrence (HR, 0.31; 95% CI: 0.12-0.78; P=0.013). No major adverse event related to the procedures occurred. Read more
