Remote Limb Preconditioning and Postconditioning

Therapies Tuesday, April 2nd, 2013

STROKEAHA: January 22, 2013

Preconditioning is an adaptive process of endogenous protection in which small, sublethal doses of a harmful agent protect the organism against a later lethal dose of the same agent. The basic principle is evident in human thought and literature, encapsulated in Nietzsche’s statement, “what does not kill me makes me stronger.”1 Ischemic preconditioning, the use of short episodes of sublethal ischemia to protect against a later episode of lethal ischemia, is one of the most effective cardioprotectants known.2Moreover, ischemic conditioning is protective in organ ischemia of multiple animal species and effective even when applied after the onset of ischemia. Read more

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