Atrial Fibrillation and Atrial Flutter in HIV-Infected Persons: Incidence, Risk Factors, and Association with Markers of HIV Disease Severity

Atrial Fibrillation Friday, April 12th, 2013

Science Direct: April 3, 2013

Objectives

The purpose of this study was to investigate the associations of traditional risk factors and longitudinal measures of HIV disease severity with risk of incident atrial fibrillation (AF) in a contemporary cohort of HIV-infected individuals.

Background

Cardiovascular disease is common in HIV-infected persons; however, the most common cardiac arrhythmia, AF, has not been adequately studied in this population.

Methods

We studied a national sample of 30,533 HIV-infected veterans followed in the Veterans Affairs HIV Clinical Case Registry from 1996-2011. We examined the independent associations of demographic characteristics, time-updated comorbidities, and time-updated clinical measurements including CD4+ cell count and viral load with the outcome of incident AF using proportional-hazards regression for multivariable analysis. Read more

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