Genetics of Stroke: The Impact and Limitations of Evolving Technology

News Friday, June 7th, 2013

Stroke June 1, 2013

There have been advances in understanding the molecular underpinnings of risk and response to stroke hailing from genetic research. Traditional linkage studies were limited to identifying genetic mutations, representing small fractions of human disease burden. Yet with large-scale genotyping, RNA expression studies and microRNA analyses, modern genetic research has opened the possibility of understanding the greater complexity of variation.

Saugstad writes of the nascent understanding of microRNAs in ischemic brain injury.1MicroRNAs regulate messenger RNA (mRNA), the template for all proteins. mRNA levels are under complex regulation. One microRNA can target several mRNAs, and 1 mRNA can be the target of several microRNAs.  Read more

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