Unipolar Signal Modification as a Guide for Lesion Creation during Radiofrequency Application in the Left Atrium: A Prospective Study in Humans in the Setting of Paroxysmal Atrial Fibrillation Catheter Ablation

CIRCEP: October 4, 2013

Background—In patients treated for paroxysmal atrial fibrillation (AF), the pulmonary vein (PV) reconnection rate is substantial and may be related to the lack of transmurality achievement while performing PV isolation (PVI). It has been experimentally demonstrated that positive unipolar atrial electrogram completion, when applying radiofrequency (RF) energy, was associated with transmural lesions. In this regard, we seek to determine whether the unipolar signal modification may be an appropriate end-point for point-by-point RF application and find out if it could improve the paroxysmal AF ablation results in humans. Read More

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