Electrophysiological Correlation and Prognostic Impact of Heat Shock Protein 27 in Atrial Fibrillation

Circep AHA Journals.org: Yu-Feng Hu1, Hung-I Yeh2, Hsuan-Ming Tsao3, Ching-Tai Tai1, Yenn-Jiang Lin1,Shih-Lin Chang1, Li-Wei Lo1, Ta-Chuan Tuan1, Kazuyoshi Suenari4,Cheng-Hung Li1, Tze-Fan Chao1 and Shih-Ann Chen1* – February 21, 2012.

Abstract

Background—HSP27 is related to the pathogenesis of AF. However, the clinical relationship between HSP27 and AF is unclear. The present study was conducted to determine the clinical relationship between heat shock protein 27 (HSP27) and atrial fibrillation (AF).

Methods and Results—A case-control study was conducted (AF, N=114; control, N=100). Serum HSP27 (HSP27S) levels were measured by ELISA, and its correlations with electrophysiological characteristics and catheter ablation outcomes were investigated. AF patients had a larger left atrial diameter (LAD), waist circumference, body mass index, and lower baseline HSP27S level than controls. After logistic multivariate analysis, low baseline HSP27S was independently associated with AF. In AF patients, those with paroxysmal AF (PAF) had higher baseline HSP27S levels compared to those with non-PAF. In PAF patients, lower baseline HSP27S was associated with larger LAD, while baseline HSP27S was not correlated with LAD in controls. In PAF, low baseline HSP27S (<3.85 ng/mL) was associated with low atrial voltage and non-pulmonary vein ectopies. In non-PAF, the mean fractionated interval had a good correlation with baseline HSP27S. After catheter ablation, a high baseline HSP27S level could predict sinus rhythm maintenance in the patients with PAF. Baseline HSP27S was also correlated with IL-10 and TNF-α levels. Analysis of buffy coat mRNA levels showed the same correlations. Read More