The Role of Statin Therapy in the Prevention of Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials

Clinical Trials Friday, March 16th, 2012

Onlinelibrary.wiley.com: Wen-tong Fang MD1, Hong-jian LI MD2, Haibo Zhang MD1, Su Jiang BD1 – March 9, 2012.

Summary

Aims:  To examine whether statins can reduce the risk of atrial fibrillation (AF).

Background:  The use of statins had been suggested to protect against AF in some clinical observational and experimental studies but has remained inadequately explored.

Methods:  Meta analysis of randomized, controlled trials with use of statins on incidence or recurrence of AF was performed.

Results:  20 studies with 23577 patients were included in the analysis. 7 studies investigated the use of statins in patients with AF, 11 studies investigated the primary prevention of statins in patients without AF, and 2 studies investigated mix population patients.  Read More

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