A Common SCN5A Variant is Associated with PR Interval and Atrial Fibrillation among African Americans

Atrial Fibrillation Thursday, August 7th, 2014

Wiley: 7/28/14

Abstract

Objective

We examined the association of rs7626962 (S1103Y) or rs7629265, a variant in high linkage disequilibrium with S1103Y (r2 = 0.87–1), with sudden cardiac death (SCD) and atrial fibrillation (AF) among African Americans.

Background

The SCN5A missense variant S1103Y has been associated with SCD among African Americans in small case-control studies, but larger population-based studies are needed to validate these findings. The association of this variant with AF has not been fully explored. Read more

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