Advanced imaging improves prediction of hemorrhage after stroke thrombolysis

Clinical Trials Sunday, December 16th, 2012

Wiley: 12/13/12

Objective:

Very low cerebral blood volume (VLCBV), diffusion and hypoperfusion lesion volumes have been proposed as predictors of hemorrhagic transformation following stroke thrombolysis. We aimed to compare these parameters, validate VLCBV in an independent cohort using DEFUSE study data and investigate the interaction of VLCBV with regional reperfusion.

Methods:

The EPITHET and DEFUSE studies obtained diffusion and perfusion MRI in patients 3-6hours from onset of ischemic stroke. EPITHET randomized patients to tPA or placebo, and all DEFUSE patients received tPA. VLCBV was defined as CBV<2.5th percentile of brain contralateral to the infarct. Parenchymal hematoma (PH) was defined using ECASS criteria. Reperfusion was assessed using subacute perfusion MRI co-registered to baseline imaging. Read More

National Minority Quality Forum Clinical Trial Engagement Network Map Childhood Obesity MapHIV Z-Atlas: Peripheral Arterial Disease Atlas Map Lung Cancer Index Z-Atlas: Chronic Kidney Disease AFIB Index Cardiometabolic Health Aliance Minority Diabetes Coalition U.S. Diabetes Index County Edition U.S. Diabetes Index Research Edition Medicare Index Medicare Index Stroke Edition About The Minority Stroke Working Group Hepatitis C Disease Index Lead Risk Index Map MRSA StrokePAD Minority Index The South Texas Diabetes Initiative Minority Stroke Consortium YouTube NMQF Videos IPAB Action Center National Health Index

© 2011 National Minority Quality Forum, Inc. All Rights Reserved.