Associations Between Incident Ischemic Stroke Events and Stroke and Cardiovascular Disease

Associations Between Incident Ischemic Stroke Events and Stroke and Cardiovascular Disease-Related GWAS SNPs in the Population Architecture Using Genomics and Epidemiology (PAGE) Study

Circgenetics.ahajournals.org: Cara L. Carty1*, Petra Bůžková2, Myriam Fornage3, Nora Franceschini4, Shelley Cole5, Gerardo Heiss4, Lucia A. Hindorff6, Barbara V. Howard7, Sue Mann1, Lisa W. Martin8, Ying Zhang9, Tara C. Matise10, Ross Prentice1, Alexander P. Reiner2 and Charles Kooperberg1 – March 8, 2012.

bstract

Background—Genome-wide association studies (GWAS) have identified loci associated with ischemic stroke (IS) and cardiovascular disease (CVD) in European-descent individuals, but their replication in different populations has been largely unexplored.

Methods and Results—Nine single-nucleotide polymorphisms (SNPs) selected from GWAS and meta-analyses of stroke and 86 SNPs previously associated with myocardial infarction and CVD risk factors including blood lipids (HDL, LDL, triglycerides), type 2 diabetes and body mass index were investigated for associations with incident IS in European Americans (EA) N=26,276; African Americans (AA) N=8970; and American Indians (AI) N= 3570 from the Population Architecture using Genomics and Epidemiology Study.  Read More