Atrial Ectopy as a Predictor of Incident Atrial Fibrillation: A Cohort Study

Atrial Fibrillation Saturday, December 14th, 2013

Ann Intern Med: 12/3/13

Background: Atrial fibrillation (AF) prediction models have unclear clinical utility given the absence of AF prevention therapies and the immutability of many risk factors. Premature atrial contractions (PACs) play a critical role in AF pathogenesis and may be modifiable.

Objective: To investigate whether PAC count improves model performance for AF risk.

Design: Prospective cohort study.

Setting: 4 U.S. communities.

Patients: A random subset of 1260 adults without prevalent AF enrolled in the Cardiovascular Health Study between 1989 and 1990.

Measurements: The PAC count was quantified by 24-hour electrocardiography. Participants were followed for the diagnosis of incident AF or death. The Framingham AF risk algorithm was used as the comparator prediction model. Read More

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