Basic Science for the Clinical Electrophysiologist

Atrial Fibrillation Friday, October 5th, 2012
Translational Research in Atrial Fibrillation: A Quest for Mechanistically Based Diagnosis and Therapy

Circep.ahajournals.org: September 27, 2012
Atrial fibrillation (AF) is the most common arrhythmia seen in clinical practice and is associated with increased risk of stroke, heart failure and death.1 However, currently available treatments for AF are less than satisfactory. Many drugs have been tried with very limited success.2 On the other hand, the demonstration of AF triggers in the atrial sleeves of the pulmonary veins (PVs)3has led to a significant improvement in therapy. Today PV isolation by means of radiofrequency (RF) ablation is a gold standard treatment for paroxysmal AF.4 However, the success rate of RF ablation in the more prevalent and highly heterogeneous persistent and long-term persistent AF populations has been disappointing. Read more

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