Orthostatic Change in Blood Pressure and Incidence of Atrial Fibrillation: Results from a Bi-Ethnic Population Based Study

PLOS: 11/11/13 Autonomic fluctuations are associated with the initiation and possibly maintenance of atrial fibrillation (AF). However, little is known about the relationship between orthostatic blood pressure change, a common manifestation of autonomic dysfunction, and incident AF. Methods We examined whether supine-to-standing changes in systolic blood pressure (SBP) are associated with incident AF in 12,071 African […]

Atrial Fibrillation Begets Myocardial Infarction

JAMA Intern Med. Published online November 04, 2013 For decades, stroke has been the principally recognized and most clinically relevant sequelae of atrial fibrillation (AF).1 However, a recent analysis demonstrated that AF may also lead to worsening renal function, a particularly important observation given that chronic kidney disease has been primarily considered a risk factor for […]

Efficacy and Safety of Apixaban in Patients Following Cardioversion for Atrial Fibrillation: Insights from the ARISTOTLE trial ONLINE FIRST

JACC:  11/1/13 Objectives  To determine the risk of major clinical and thromboembolic events after cardioversion for atrial fibrillation in subjects treated with apixaban, an oral factor Xa inhibitor compared with warfarin. Background  In patients with atrial fibrillation (AF), thromboembolic events may occur after cardioversion. This risk is lowered with vitamin K antagonists and dabigatran. Read more

Vitamin E Serum Levels and Bleeding Risk in Patients Receiving Oral Anticoagulant Therapy: a Retrospective Cohort Study

J Am Heart Assoc.:  October 28, 2013 Background Hemorrhagic risk assessment is a crucial issue in patients with nonvalvular atrial fibrillation (NVAF) who are receiving oral anticoagulant therapy (OAT). Our aim was to analyze the relationship between vitamin E, which possesses anticoagulant properties, and bleeding events in NVAF patients. Methods and Results In this retrospective observational study […]

Atrial Fibrillation Patterns and Risks of Subsequent Stroke, Heart Failure, or Death in the Community

J Am Heart Assoc.:  September 3, 2013 Background Atrial fibrillation (AF) patterns and their relations with long‐term prognosis are uncertain, partly because pattern definitions are challenging to implement in longitudinal data sets. We developed a novel AF classification algorithm and examined AF patterns and outcomes in the community. Methods and Results We characterized AF patterns between 1980 and […]

An Updated Review of Target‐Specific Oral Anticoagulants Used in Stroke Prevention in Atrial Fibrillation, Venous Thromboembolic Disease, and Acute Coronary Syndromes

J Am Heart Assoc: October 23, 2013 Atrial fibrillation (AF) is a common arrhythmia in the adult population. It is associated with up to a 5‐fold increased risk of stroke and contributes to a higher morbidity and mortality compared with non–AF‐related strokes.1 The current prevalence of AF in the adult population, estimated at 1% to 2%, is […]

Plasma Phospholipid Omega‐3 Fatty Acids and Incidence of Postoperative Atrial Fibrillation in the OPERA Trial

J Am Heart Assoc.: October 21, 2013 Background Long‐chain polyunsaturated omega‐3 fatty acids (n‐3 PUFA) demonstrated antiarrhythmic potential in experimental studies. In a large multinational randomized trial (OPERA), perioperative fish oil supplementation did not reduce the risk of postoperative atrial fibrillation (PoAF) in cardiac surgery patients. However, whether presupplementation habitual plasma phospholipid n‐3 PUFA, or achieved or […]

Differential Clinical Characteristics and Prognosis of Patients with Longstanding Persistent Atrial Fibrillation Presenting with Recurrent Atrial Tachycardia versus Recurrent Atrial Fibrillation after First Ablation

Journal of Cardiovascular Electrophysiology: 10/1/2013 Background It is unknown if baseline characteristics and prognosis of patients with longstanding persistent (defined as history greater than 1 year) atrial fibrillation (LS-AF) differ among those with either recurrent atrial tachycardia (R-AT) or recurrent AF (R-AF) after first ablation. Methods In 222 consecutive LS-AF patients treated for R-AT or […]

Novel Oral Anticoagulants Versus Warfarin Therapy at Various Levels of Anticoagulation Control in Atrial Fibrillation—A Cost-Effectiveness Analysis

Journal of General Internal Medicine: October 2013 The decision as to whether to use more expensive novel oral anticoagulants (NOACs) or invest resources for quality improvement of warfarin therapy requires input from both clinical and economic analyses. OBJECTIVE Cost-effectiveness of NOACs compared to warfarin therapy at various levels of patient-time in therapeutic range (TTR) in patients […]

Catheter Ablation of Atrial Fibrillation in Hypertrophic Cardiomyopathy: Long-Term Outcomes and Mechanisms of Arrhythmia Recurrence

CIRCEP: October 10, 2013 Background—Pulmonary vein antrum isolation (PVAI) in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) has been reported to have satisfactory results at the mid and short-term follow-up. We determined the outcomes at the long-term follow-up of PVAI in these patients. Methods and Results—We enrolled 43 patients with HCM and AF (28% […]

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