Cost Effectiveness of Treatments for Stroke Prevention in Atrial Fibrillation: Focus on the Novel Oral Anticoagulants

Springer: October 2, 2013 For more than 5 decades, the only available treatment for the prevention of atrial fibrillation (AF)-related stroke were the vitamin K antagonists. Recently, novel oral anticoagulants (NOAC) have been approved for the prevention of AF-related stroke. In the present article, the cost effectiveness of AF-related stroke-prevention strategies is reviewed. The emphasis on […]

Local Innervation and Atrial Fibrillation

CIRCULATIONAHA:  10/1/13 Atrial fibrillation (AF) is the most common human arrhythmia in the world and, depending on individual demographics, afflicts from 0.1% to 4% of the general population.1 With the steady rise of cardiovascular disease in the industrialized world, it is no surprise that the incidence of AF is also increasing.2,3 However, despite its ubiquitous presence in […]

Novel oral anticoagulants for stroke prevention in atrial fibrillation: results of the European Heart Rhythm Association survey

Europace: 10/1/13 The purpose of this European Heart Rhythm Association (EHRA) survey was to assess clinical practice in relation to stroke prevention in atrial fibrillation (AF), particularly into the use of novel oral anticoagulants (NOACs) for stroke prevention, among members of the EHRA electrophysiology (EP) research network. In this EP Wire survey, we have provided some […]

Neuropathologic Changes Associated With Atrial Fibrillation in a Population-Based Autopsy Cohort

J Gerontol A Biol Sci Med Sci: September 28, 2013 Background. Atrial fibrillation (AF) is associated with higher risk of dementia and Alzheimer’s disease. To better understand the mechanism, we examined neuropathologic changes seen with AF. Methods. We analyzed data from an autopsy series arising from a population-based, prospective cohort study set within Group Health, an integrated health […]

Increasing time between first diagnosis of atrial fibrillation and catheter ablation adversely affects long-term outcomes

Heart Rhythm Journal: 5/22/13 Background Many patients who develop atrial fibrillation (AF) will experience a worsening of their arrhythmia over time. The optimal time to proceed with catheter ablation during the disease course is unknown. Further, whether delays in treatment will negatively influence outcomes is unknown. Objective The purpose of this study was to examine the […]

Health Services and Outcomes Research

J Am Heart Assoc.: September 26, 2013 Racial Differences in the Prevalence and Outcomes of Atrial Fibrillation Among Patients Hospitalized With Heart Failure Background The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence […]

Anticoagulant therapy is underused in high-risk atrial fibrillation

MNT: Sept. 26,  2013 AMSTERDAM – Investigators are reporting widespread underuse of anticoagulant therapy in patients with atrial fibrillation (AF) who are at high risk of stroke, despite the fact that such therapy is known to decrease stroke risk in this population. The findings were released at the European Society of Cardiology (ESC) Congress 2013 […]

Inhospital Complications Associated with Catheter Ablation of Atrial Fibrillation in the United States between 2000-2010: Analysis of 93,801 Procedures

CIRCULATIONAHA: September 23, 2013 Background—AF ablation has tremendous progress with respect to innovation, efficacy and safety. However limited data exists regarding burden and trends in adverse outcomes arising from this procedure. The aim of our study was to examine frequency of adverse events due to Atrial Fibrillation (AF) ablation and influence of operator and hospital volume […]

Preventing Stroke in Patients With Chronic Kidney Disease and Atrial Fibrillation

AHA Stroke: September 5, 2013 Chronic kidney disease (CKD) is a major global health problem. It is defined by decreased kidney function (characterized by a reduced estimated glomerular filtration rate [eGFR] <60 mL/min per 1.73 m2) and kidney damage characterized by albuminuria or proteinuria.1 To standardize definitions and facilitate risk stratification, 5 different stages of severity have […]

Renal Dysfunction, Stroke Risk Scores (CHADS2, CHA2DS2-VASc and R2CHADS2) and the Risk of Thromboembolic Events after Catheter Ablation of Atrial Fibrillation: The Leipzig Heart Center AF Ablation Registry

AHA: CIRCEP: September 18, 2013 Background—There are limited data on the predictive value of stroke risk scores for thromboembolic events (TE) after catheter ablation of atrial fibrillation (AF). Our objectives were to report the incidence of TE after AF ablation in a large contemporary AF ablation cohort. Methods and Results—Using the Leipzig Heart Center AF Ablation […]

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