Atrial Remodeling Role in Atrial Fibrillation Ablation

Jafib: January 13th, 2013 There have been considerable advances in understanding the relationship of atrial fibrillation (AF) and atrial remodelling suggesting that remodelling states have a significant impact on treatment results. Therefore, we reviewed the literature about the role of atrial remodelling in AF treatment, focussing on AF ablation. Atrial fibrillatory activity, dominant frequencies (DF), complex fractionated atrial […]

Incident Atrial Fibrillation and Risk of End-Stage Renal Disease in Adults with Chronic Kidney Disease

CIRCULATIONAHA: December 28, 2012 Background—Atrial fibrillation (AF) frequently occurs in patients with chronic kidney disease (CKD). However, the long-term impact of development of AF on the risk of adverse renal outcomes in patients with CKD is unknown. In this study, we determined the association between incident AF and risk of end-stage renal disease (ESRD) among adults […]

Temporal Trends in Ischemic Stroke and Anticoagulation Therapy Among Medicare Patients With Atrial Fibrillation

A 15-Year Perspective (1992-2007) JAMA: 12/24/12 A trial fibrillation (AF) is an independent, modifiable risk factor for ischemic stroke1 and independently associated with increased mortality.2 Nonvalvular AF is associated with a nearly 5-fold higher risk of ischemic stroke; this risk progressively increases with age.3 In a meta-analysis involving 29 clinical studies and 28 044 patients, judicious antithrombotic therapy with […]

Prevalence of unknown atrial fibrillation in patients with risk factors

Europace: December 20, 2012 Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia. ‘Silent’, undiagnosed AF is often only detected with the first complication, e.g. a stroke. Detection of ‘silent’ AF prior to the first cerebrovascular event would be valuable to institute adequate therapy and prevent complications related to AF. We performed a simple electrocardiography (ECG) […]

2012 ACCF/AHA/HRS Focused Update Incorporated Into the ACCF/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities

Ahajournals: 12/19/12 It is important that the medical profession play a significant role in critically evaluating the use of diagnostic procedures and therapies as they are introduced and tested in the detection, management, or prevention of disease states. Rigorous and expert analysis of the available data documenting absolute and relative benefits and risks of those procedures and therapies can produce helpful […]

Interdependent relationship between atrial fibrillation and sinus rhythm

Interdependent relationship between atrial fibrillation and sinus rhythm: at the hypothetical interface of atrial fibrillation, autonomic tone, sinoatrial node and inflammation (analytical review, reconsiderations, speculations and new insights) Jafib: 12/20/12 Abstract. Underlying mechanisms of atrial fibrillation occurrence and its self-extinguishing remain not completely investigated yet. The role of autonomic tone and sinoatrial node in the interplay […]

FDA Drug Safety Communication: Pradaxa (dabigatran etexilate mesylate) should not be used in patients with mechanical prosthetic heart valves

FDA: 12-19-2012 The U.S. Food and Drug Administration (FDA) is informing health care professionals and the public that the blood thinner (anticoagulant) Pradaxa (dabigatran etexilate mesylate) should not be used to prevent stroke or blood clots (major thromboembolic events) in patients with mechanical heart valves, also known as mechanical prosthetic heart valves. A clinical trial […]

Familial Atrial Fibrillation Predicts Increased Risk of Mortality: A Study in Danish Twins

AHA: 12/19/12 Background—Atrial fibrillation (AF) is a common arrhythmia. Several studies have shown association of genetic variants with AF, and that familial AF increases the risk of AF. We have previously shown a substantial heritability of AF in a twin study. The objective of this study was to determine whether having a co-twin with AF […]

Clinical Implication of Adenosine Test at Repeat Atrial Fibrillation Ablation Procedure

The Importance of Detecting Dormant Thoracic Vein Conduction AHA: 10/24/12 Background—Pulmonary vein reconnection after electrical isolation is commonly observed in the context of atrial fibrillation ablation and is associated with recurrent atrial tachyarrhythmias. Adenosine test was been performed to identify acute dormant conduction immediately after pulmonary vein isolation at index procedure. However, the utility of […]

Mechanisms of Human Atrial Fibrillation Initiation

AHA: October 1, 2012 Clinical and Computational Studies of Repolarization Restitution and Activation Latency Background—Mechanisms of atrial fibrillation (AF) initiation are incompletely understood. We hypothesized that rate-dependent changes (restitution) in action potential duration (APD) and activation latency are central targets for clinical interventions that induce AF. We tested this hypothesis using clinical experiments and computer […]

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