Impact of Metabolic Syndrome on Left Atrial Electro-Anatomical Remodeling and Outcomes after Radiofrequency Ablation of Non Valvular Atrial Fibrillation

​CIRCEP: 5/15/14 Background—Recent studies reported worse outcomes after atrial fibrillation (AF) ablation in patients with metabolic syndrome (MetS). However, mechanisms of AF recurrence in MetS remain unclear. Method and Results—We performed pulmonary vein isolation and voltage mapping in two hundred thirty-six AF patients (age 61±9.6 y.; persistent AF 64%, MetS 54%). LA low-voltage (LoVo) areas were […]

Prescription frequency and predictors for the use of novel direct oral anticoagulants for secondary stroke prevention in the first year after their marketing in Europe – a multicentric evaluation

Wiley: 5/15/14 Background Direct oral anticoagulants (DOAC) are alternatives to the use of vitamin K antagonists (VKA) as oral anticoagulant therapies to prevent stroke in patients with atrial fibrillation. Aims We assembled a representative secondary prevention cohort from four tertiary care stroke centers to identify factors that independently influence therapeutic decision making 1) not to anticoagulate […]

Pulmonary Veins to Left Atrium Cycle Length Gradient Predicts Procedural and Clinical Outcomes of Persistent Atrial Fibrillation Ablation

CIRCEP: May 14, 2014 Background—Rapid pulmonary vein (PV) activity has been shown to maintain paroxysmal AF. We evaluated in persistent AF (PsAF) the cycle length (CL) gradient between PVs and the left atrium (LA) in an attempt to identify the subset of patients where PVs play an important role. Methods and Results—97 consecutive patients undergoing first […]

Predisposing Factors Associated With Development of Persistent Compared With Paroxysmal Atrial Fibrillation

J Am Heart Assoc: May 1, 2014 Background Once atrial fibrillation (AF) progresses to sustained forms, adverse outcomes increase and treatment success rates decrease. Therefore, identification of risk factors predisposing to persistence of AF may have a significant impact on AF morbidity. Methods and Results We prospectively examined the differential associations between traditional, lifestyle, and biomarker AF risk […]

Historical Context and Detailed Translational Perspective on an Important Clinical Problem

CIRCRESAHA: 4/25/14 Circulation Research Compendium on Atrial Fibrillation: Atrial Fibrillation Compendium: Historical Context and Detailed Translational Perspective on an Important Clinical Problem The Clinical Profile and Pathophysiology of Atrial Fibrillation: Relationships Among Clinical Features, Epidemiology, and Mechanisms Emerging Directions in the Genetics of Atrial Fibrillation Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance and Progression Role […]

RACIAL DISPARITIES IN HOSPITALIZATIONS, PROCEDURAL TREATMENTS AND MORTALITY OF PATIENTS HOSPITALIZED WITH ATRIAL FIBRILLATION

Ishib: 4/9/14 Objectives: To explore racial differences in characteristics, procedural treatments, and mor- tality of hospitalized atrial fibrillation (AF) patients. Background: Despite a higher burden of AF risk factors, Black individuals have a lower prevalence of AF than their White counterparts. There is suggestion that AF may go undetected in minority groups, and there may be […]

Long-Term Follow-Up After Catheter Ablation of Paroxysmal Atrial Fibrillation

Circulation: Arrhythmia and Electrophysiology:  March 7, 2014 The Incidence of Recurrence and Progression of Atrial Fibrillation Background—Although catheter ablation (CA) is a standard treatment for atrial fibrillation (AF), its long-term efficacy remains unclear. This study aimed to elucidate the incidences of AF recurrence and of progression from paroxysmal to persistent AF, after CA, in patients […]

Variations in Cause and Management of Atrial Fibrillation in a Prospective Registry of 15 400 Emergency Department Patients in 46 Countries

CIRCULATIONAHA: January 24, 2014   Background—Atrial fibrillation (AF) is the most common sustained arrhythmia; however, little is known about patients in a primary care setting from high-, middle-, and low-income countries. Methods and Results—This prospective registry enrolled patients presenting to an emergency department with AF at 164 sites in 46 countries representing all inhabited continents. Patient […]

Non-steroidal anti-inflammatory drugs and the risk of atrial fibrillation: a population-based follow-up study

April 8, 2014 Abstract Objective To investigate the association of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of atrial fibrillation in a prospective community-based follow-up study of elderly individuals with uniform case assessment and data on potential confounders. Design Data came from the population-based follow-up study, the Rotterdam Study. Participants The study comprised 8423 participants without atrial fibrillation […]

Assessment of long-term quality of life after cavotricuspid isthmus ablation for typical atrial flutter

Health and Quality of Life Outcomes: April 7, 2014 Background Cavotricuspid isthmus (CTI) ablation is the treatment of choice in preventing recurrences of typical atrial flutter (AFl). However, little is known about long-term quality of life (QoL) after CTI ablation. Methods and results From 01/2003 to 05/2005, 94 patients who consecutively underwent typical AFl ablation were […]

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