Clinical Trials
Saturday, December 14th, 2013
The Lancet: October 26, 2013 Background Early results of the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis trial showed that, by 30 days, 33 (14·7%) of 224 patients in the stenting group and 13 (5·8%) of 227 patients in the medical group had died or had a stroke (percentages are […]
Clinical Trials
Friday, November 22nd, 2013
Medpagetoday: 11/21/13 DALLAS — A pacemaker set to pace only when and where needed improved patient outcomes, particularly the risk of permanent atrial fibrillation, a trial showed. The sophisticated predictive, right-ventricle sparing programming was associated with a 26% reduction in risk of death from any cause, cardiovascular-related hospitalization, or permanent afib compared with standard dual-chamber pacing […]
Clinical Trials
Friday, November 22nd, 2013
JAMA: November 20, 2013 Importance Obesity is a risk factor for atrial fibrillation. Whether weight reduction and cardiometabolic risk factor management can reduce the burden of atrial fibrillation is not known. Objective To determine the effect of weight reduction and management of cardiometabolic risk factors on atrial fibrillation burden and cardiac structure. Design, Setting, and Patients Single-center, partially blinded, randomized […]
Clinical Trials
Friday, November 22nd, 2013
Medpagetoday: Nov 20, 2013 DALLAS — Ablating the atrial chamber substrate for prevention of paroxysmalatrial fibrillation appears to be noninferior to the standard method of ablating suspected triggers in the pulmonary veins, researchers reported here. Of 58 patients treated with circumferential pulmonary vein ablation, 40, or 69%, achieved freedom from paroxysmal bouts of atrial fibrillation at 12 […]
Clinical Trials
Friday, November 22nd, 2013
NEJM: 11/19/13 BACKGROUND The clinical utility of genotype-guided (pharmacogenetically based) dosing of warfarin has been tested only in small clinical trials or observational studies, with equivocal results. Full Text of Background… METHODS We randomly assigned 1015 patients to receive doses of warfarin during the first 5 days of therapy that were determined according to a […]
Clinical Trials
Friday, November 22nd, 2013
NEJM: 11/19/13 Observational evidence suggests that the use of a genotype-guided dosing algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon therapy. Full Text of Background… METHODS We conducted two single-blind, randomized trials comparing a genotype-guided dosing algorithm that included clinical variables and genotyping for CYP2C9 and VKORC1 with a dosing algorithm that included only clinical variables, for […]
Clinical Trials
Monday, November 18th, 2013
JAMA: 11/17/13 Importance Although the benefit of reducing blood pressure for primary and secondary prevention of stroke has been established, the effect of antihypertensive treatment in patients with acute ischemic stroke is uncertain. Objective To evaluate whether immediate blood pressure reduction in patients with acute ischemic stroke would reduce death and major disability at 14 days or hospital […]
Clinical Trials
Monday, November 18th, 2013
ASA: 11/12/13 Atrial fibrillation (AF) is the most common type of arrhythmia in adults and becomes more common with increased age. Management of people with AF aims at preventing thromboembolic complications, and anticoagulant treatment with vitamin K antagonists (VKAs) has been the therapy of choice for many decades. A new class of anticoagulants, the factor Xa […]
Clinical Trials
Monday, November 18th, 2013
CIRCOUTCOMES: November 12, 2013 Impact of a Multimodal Support Intervention After a Mild Stroke Background—Comparison of a multimodal intervention WE CALL (study initiated phone support/information provision) versus a passive intervention YOU CALL (participant can contact a resource person) in individuals with first mild stroke. Methods and Results—This study is a single-blinded randomized clinical trial. Primary outcome […]
Clinical Trials
Monday, November 18th, 2013
CIRCULATIONAHA: September 9, 2013 A Competing-Risk Analysis From the Randomized Evaluation of Long-Term Anticoagulant Therapy Study Background—Atrial fibrillation is associated with increased mortality, but the specific causes of death and their predictors have not been described among patients on effective anticoagulant therapy. Methods and Results—The Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial randomized 18 113 patients […]
