Clinical Trials
Tuesday, November 12th, 2013
STROKEAHA: November 7, 2013 Background and Purpose—Therapeutic hypothermia improves outcomes in experimental stroke models, especially after ischemia-reperfusion injury. We investigated the clinical and radiological effects of therapeutic hypothermia in acute ischemic stroke patients after recanalization. Methods—A prospective cohort study at 2 stroke centers was performed. We enrolled patients with acute ischemic stroke in the anterior circulation […]
Clinical Trials
Tuesday, November 12th, 2013
Clin Trials: November 4, 2013 Background The use of decision-support interventions in the context of decisions about trial participation is an emergent field. There is a lack of evidence about what information is deemed important to support decisions about informed consent for clinical trials, and whether different groups agree on the information for inclusion. Purpose The overall objective […]
Clinical Trials
Tuesday, November 12th, 2013
Biostatistics: 9/27/13 It is often suspected (or known) that outcomes published in medical trials are selectively reported. A systematic review for a particular outcome of interest can only include studies where that outcome was reported and so may omit, for example, a study that has considered several outcome measures but only reports those giving significant results. […]
Clinical Trials
Monday, November 4th, 2013
STROKEAHA: October 31, 2013 Background and Purpose—The ability to live independently after stroke depends on the recovery of upper limb function. We hypothesized that bilateral priming with active–passive movements before upper limb physiotherapy would promote rebalancing of corticomotor excitability and would accelerate upper limb recovery at the subacute stage. Methods—A single-center randomized controlled trial of bilateral […]
Clinical Trials
Monday, November 4th, 2013
BMJ: 10/29/13 Objective To estimate the frequency with which results of large randomized clinical trials registered with ClinicalTrials.gov are not available to the public. Design Cross sectional analysis Setting Trials with at least 500 participants that were prospectively registered with ClinicalTrials.gov and completed prior to January 2009. Data sources PubMed, Google Scholar, and Embase were searched to identify published manuscripts containing […]
Clinical Trials
Monday, November 4th, 2013
FDA: 10/29/13 Personalized medicine is the tailoring of a medical treatment to the individual characteristics, needs and preferences of a patient. Many recent advances involve using a patient’s genetic information to guide his or her treatment. Developing a truly personalized approach to patient care will require fundamental advances in the understanding of the biological, anatomical […]
Clinical Trials
Monday, November 4th, 2013
CIRCEP: October 25, 2013 Background—The role of subsequent atrial tachycardias (AT) in the context of persistent atrial fibrillation (AF) remains undetermined. This study evaluated the prognostic role of subsequent ATs for arrhythmia recurrences following catheter ablation of persistent AF. Methods and Results—A total of 110 patients with persistent AF (63±9 y, 22 female, 61 long-lasting persistent […]
Clinical Trials
Monday, November 4th, 2013
STROKEAHA: October 24, 2013 Background and Purpose—The Combined Lysis of Thrombus in Brain Ischemia With Transcranial Ultrasound and Systemic T-PA-Hands-Free (CLOTBUST-HF) study is a first-in-human, National Institutes of Health–sponsored, multicenter, open-label, pilot safety trial of tissue-type plasminogen activator (tPA) plus a novel operator-independent ultrasound device in patients with ischemic stroke caused by proximal intracranial occlusion. Methods—All […]
Clinical Trials
Friday, November 1st, 2013
International Journal of Stroke: OCT 22, 2013 Background The National Institutes of Neurological Disorders and Stroke and the European Co-operative Acute Stroke III trials enrolled a largely Caucasian population, but the results are often extrapolated onto non-Caucasians. A limited number of nonrandomized studies have proposed that non-Caucasian patients show differential response to tissue plasminogen activator. Aims […]
Clinical Trials
Friday, November 1st, 2013
International Journal of Stroke: OCT 22, 2013 Background and aims Cardiovascular co-morbidities are prevalent after stroke, with heart disease, hypertension and impaired glucose tolerance present in the majority of cases. Exercise has the potential to mediate cardiovascular risk factors commonly present in people with stroke. This single-blinded randomized controlled trial compared the effects of high versus […]
