Clinical Trials
Friday, November 1st, 2013
International Journal of Stroke: OCT 22, 2013 Background Risk profiles for stroke recurrence are poorly characterized. Aims We determined the variation in the risk and type of recurrent stroke among index ischemic stroke subtypes, and whether index stroke subtype and conventional stroke risk factors were predictors of stroke recurrence. Methods Patients enrolled in the Prevention Regimen […]
Clinical Trials
Friday, November 1st, 2013
STROKEAHA: October 10, 2013 The recent results of the Interventional Management of Stroke III (IMS-III)1 and SYNTHESIS Expansion2 trials have brought forth a hard wave of skepticism on the use of endovascular therapy in acute ischemic stroke reinforcing more than ever the nihilistic behavior that has afflicted this field since its inception.3 As research results are only generalizable […]
Clinical Trials
Monday, October 21st, 2013
STROKEAHA: October 17, 2013 Background and Purpose—Early vascular events are an important cause of morbidity and mortality in the first 3 months after a stroke. We aimed to investigate the effects of MLC601 on the occurrence of early vascular events within 3 months of stroke onset. Methods—Post hoc analysis was performed on data from subjects included […]
Clinical Trials
Monday, October 21st, 2013
STROKEAHA: October 17, 2013 Background and Purpose—A high rate of postprocedure complications in the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial has raised concerns whether such results are representative of intracranial stent placement in actual routine practice. Methods—Using the Nationwide Inpatient Sample from 2008 to 2010, patients with cerebral ischemic events treated […]
Clinical Trials
Monday, October 21st, 2013
Eur Heart J: October 15, 2013 Aims We investigated the prevalence of prior myocardial infarction (MI) and incidence of ischaemic cardiovascular (CV) events among atrial fibrillation (AF) patients. Methods and results In ROCKET AF, 14 264 patients with nonvalvular AF were randomized to rivaroxaban or warfarin. The key efficacy outcome for these analyses was CV death, MI, and […]
Clinical Trials
Monday, October 21st, 2013
STROKEAHA: October 10, 2013 Background and Purpose—Hallmarks of vulnerable atherosclerotic plaques are inflammation that can be assessed with 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography, and increased neovascularization that can be evaluated by dynamic contrast–enhanced-MRI. It remains unclear whether these parameters are correlated or represent independent imaging parameters. This study determines whether there is a correlation between inflammation and […]
Clinical Trials
Monday, October 21st, 2013
JACC: October 2013 Objectives Analyze the impact of dabigatran plasma concentrations, patient demographics and ASA use on frequencies of ischemic strokes/systemic emboli and major bleeds in atrial fibrillation patients . Background The efficacy and safety of dabigatran etexilate were demonstrated in the RE-LY trial, but a therapeutic concentration range has not been defined. Methods In a prespecified analysis […]
Clinical Trials
Thursday, October 10th, 2013
CIRCEP: October 4, 2013 Background—In patients treated for paroxysmal atrial fibrillation (AF), the pulmonary vein (PV) reconnection rate is substantial and may be related to the lack of transmurality achievement while performing PV isolation (PVI). It has been experimentally demonstrated that positive unipolar atrial electrogram completion, when applying radiofrequency (RF) energy, was associated with transmural lesions. […]
Clinical Trials
Thursday, October 10th, 2013
J Am Coll Cardiol: 10/1/13 Objectives This study was designed to assess whether the reinforcement of the antioxidant system, through n-3 fatty acids plus antioxidant vitamin supplementation, could reduce the incidence of post-operative atrial fibrillation. Background Therapy to prevent post-operative atrial fibrillation remains suboptimal. Although oxidative stress plays a key role in the pathogenesis of this arrhythmia, […]
Clinical Trials
Thursday, October 10th, 2013
J Am Coll Cardiol: 10/1/13 Objectives This study was designed to assess whether the reinforcement of the antioxidant system, through n-3 fatty acids plus antioxidant vitamin supplementation, could reduce the incidence of post-operative atrial fibrillation. Background Therapy to prevent post-operative atrial fibrillation remains suboptimal. Although oxidative stress plays a key role in the pathogenesis of this […]
