Clinical Trials
Thursday, September 5th, 2013
Medicalxpress: September 1, 2013 In patients with atrial fibrillation, delayed enhancement magnetic resonance imaging (DE-MRI) performed before ablative treatment can stage the degree of damaged heart tissue (atrial fibrosis) and help predict whether treatment will be successful or not, according to results of Delayed Enhancement – MRI determinant of successful Catheter Ablation of Atrial Fibrillation (DECAAF) […]
Clinical Trials
Thursday, September 5th, 2013
Medicalxpress: September 1, 2013 Stroke is the second cause of death worldwide. Atrial fibrillation is the most common clinically relevant cardiac arrhythmia in Europe, affecting approximately 1.5-2% of the general population.1 Prevalence is estimated to double in the next 50 years as the population ages. Patients with atrial fibrillation have a five-fold increased risk of ischaemic stroke even […]
Clinical Trials
Thursday, September 5th, 2013
CIRCEP: August 29, 2013 Background—Magnetic resonance imaging (MRI)-detected brain lesions are common following left atrial catheter ablation (LACA) for symptomatic atrial fibrillation. The clinical relevance of these acute ischemic lesions is not fully understood, but ablation-related cerebral injury could contribute to cognitive dysfunction. Methods and Results—In the prospective “Mesh Ablator versus Cryoballoon Pulmonary Vein Ablation of […]
Clinical Trials
Friday, August 30th, 2013
STROKEAHA: 7/29/13 Background and Purpose—To investigate the association of low estimated glomerular filtration rate (eGFR) <60 mL/min with recurrent stroke risk and to evaluate whether add-on renin–angiotensin system modulator therapy is associated with lower recurrent stroke risk in patients with low eGFR. Methods—We analyzed the database of a multicenter trial involving 18 666 patients with […]
Clinical Trials
Friday, August 30th, 2013
Implementation Science: August 23, 2013 Medical Research Council (MRC) guidance identifies implementation as a key element of the development and evaluation process for complex healthcare interventions. Implementation is itself a complex process involving the mobilization of human, material, and organizational resources to change practice within settings that have pre-existing structures, historical patterns of relationships, and routinized […]
Clinical Trials
Friday, August 30th, 2013
J Am Heart Assoc: August 20, 2013 Background The purpose of this study was to determine whether interventions including components to improve adherence to antihypertensive medications in patients after stroke/transient ischemic attack (TIA) improve adherence and blood pressure control. Methods and Results We searched MEDLINE, EMBASE, CINAHL, BNI, PsycINFO, and article reference lists to October 2012. Search terms […]
Clinical Trials
Friday, August 30th, 2013
STROKEAHA: 7/18/13 A Meta-analysis of Patent Foramen Ovale Closure Trials Until recently, the evidence base for patent foramen ovale (PFO) closure with a device to prevent future cerebrovascular events in patients with cryptogenic stroke and presumed paradoxical embolism consisted of a large body of >50 observational studies that cumulatively showed substantial and unequivocal benefits with […]
Clinical Trials
Friday, August 30th, 2013
STROKEAHA: 7/18/13 Background and Purpose—Minocycline, in animal models and 2 small randomized controlled human trials, is a promising neuroprotective agent in acute stroke. We analyzed the efficacy and safety of intravenous minocycline in acute ischemic and hemorrhagic stroke. Methods—A multicenter prospective randomized open-label blinded end point evaluation pilot study of minocycline 100 mg administered intravenously, commenced […]
Clinical Trials
Friday, August 23rd, 2013
STROKEAHA: August 20, 2013 Background and Purpose—Granulocyte colony–stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose–escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients.Read More
Clinical Trials
Friday, August 23rd, 2013
STROKEAHA: August 13, 2013 Background and Purpose—Surgical decompression reduces mortality and increases the probability of a favorable functional outcome after space-occupying hemispheric infarction. Its cost-effectiveness is uncertain. Methods—We assessed clinical outcomes, costs, and cost-effectiveness for the first 3 years in patients who were randomized to surgical decompression or best medical treatment within 48 hours after symptom […]
