Nature – June 05, 2013 It is time for a far-reaching and comprehensive review of the way US government-backed clinical research is funded and approved. Ethical reviews of much of this work are currently inadequate and problems come to light too late. In the most recent example, the US Department of Health and Human Services […]
The Cochrane Library – JUN 4, 2013 Current guidelines recommend oral anticoagulation therapy for patients with atrial fibrillation who are at moderate-to-high risk of stroke, however anticoagulation control (time in therapeutic range (TTR)) is dependent on many factors. Educational and behavioural interventions may impact on patients’ ability to maintain their International Normalised Ratio (INR) control. […]
AHA – June 4, 2013 Background and Purpose—The goal of this randomized, open-label phase II study was to investigate the effect of concomitant low-frequency head-motion therapy and intraventricular fibrinolysis in patients after surgical or endovascular treatment for aneurysmal subarachnoid hemorrhage. Methods—Sixty patients experiencing subarachnoid hemorrhage were randomized into treatment with intraventricular application of recombinant tissue-type […]
Stroke: June 1, 2013 Intracerebral hemorrhage (ICH) accounts for 10% to 15% of all strokes. ICH continues to impart a considerable degree of morbidity and mortality, with 30-day mortality ranging from 44% to 50%.1–3 ICH remains a devastating disease, and current treatment options lag far behind those for ischemic stroke. There are no approved therapies, which […]
The Lancet: May 29, 2013 Background Lowering of blood pressure prevents stroke but optimum target levels to prevent recurrent stroke are unknown. We investigated the effects of different blood-pressure targets on the rate of recurrent stroke in patients with recent lacunar stroke. Methods In this randomised open-label trial, eligible patients lived in North America, Latin […]
J NeuroIntervent Surgery: May 28, 2013 Background and purpose The use of stentrievers (ST) is rapidly growing due to several potential benefits over other available treatments. ST potentially restore flow before clot retrieval and reduce procedural time. We aimed to study the impact of these potential benefits. Methods Patients with acute stroke treated with endovascular procedures in […]
Medical Xpress: May 27, 2013 Updated interim data from the PISCES trial, which has seen the brains of ischaemic stroke patients injected with neural stem cells to test the safety and tolerability of the treatment, was presented to the 22nd European Stroke Conference in London today. Professor Keith Muir of the University of Glasgow, who is […]
Stroke. May 16, 2013 The Solitaire With the Intention for Thrombectomy (SWIFT) trial1 and the TREVO II trial,2published online in Lancet in August 2012, are important trials in the history of endovascular therapy for acute ischemic stroke for several reasons. First, both randomized trials compared a new technology, 2 versions of a stent-retriever, with a previously Food and […]
JACC: May 28, 2013 Post-operative atrial fibrillation (PoAF) is among the most common complications of cardiac surgery and substantially increases morbidity and healthcare costs. Despite decades of surgical, anesthetic, and medical advances, rates of PoAF remain largely unchanged. Experiments and animal models suggest that perioperative fish oil (omega-3 fatty acids) may reduce PoAF (1). We […]
International Journal of Stroke: May 22, 2013 Background It remains controversial whether dual antiplatelet therapy reduces stroke more than aspirin alone. Aim We aimed to assess the effects of adding clopidogrel to aspirin on the occurrence of stroke and major haemorrhage in patients with vascular disease. Methods Meta-analysis of published randomized trials comparing the combination […]
